Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders
The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory land...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24243-0 |
| _version_ | 1818952040165933056 |
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| author | Benxia Hu Hyejung Won Won Mah Royce B. Park Bibi Kassim Keeley Spiess Alexey Kozlenkov Cheynna A. Crowley Sirisha Pochareddy The PsychENCODE Consortium Yun Li Stella Dracheva Nenad Sestan Schahram Akbarian Daniel H. Geschwind |
| author_facet | Benxia Hu Hyejung Won Won Mah Royce B. Park Bibi Kassim Keeley Spiess Alexey Kozlenkov Cheynna A. Crowley Sirisha Pochareddy The PsychENCODE Consortium Yun Li Stella Dracheva Nenad Sestan Schahram Akbarian Daniel H. Geschwind |
| author_sort | Benxia Hu |
| collection | DOAJ |
| description | The cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory landscapes in the human brain, and provide insights into cell-type-specific gene regulatory networks in brain disorders. |
| first_indexed | 2024-12-20T09:44:03Z |
| format | Article |
| id | doaj.art-58d534607fbd40f0b3a815f520ae49df |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T09:44:03Z |
| publishDate | 2021-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-58d534607fbd40f0b3a815f520ae49df2022-12-21T19:44:47ZengNature PortfolioNature Communications2041-17232021-06-0112111310.1038/s41467-021-24243-0Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disordersBenxia Hu0Hyejung Won1Won Mah2Royce B. Park3Bibi Kassim4Keeley Spiess5Alexey Kozlenkov6Cheynna A. Crowley7Sirisha Pochareddy8The PsychENCODE ConsortiumYun Li9Stella Dracheva10Nenad Sestan11Schahram Akbarian12Daniel H. Geschwind13UNC Neuroscience Center, University of North CarolinaUNC Neuroscience Center, University of North CarolinaUNC Neuroscience Center, University of North CarolinaFriedman Brain Institute, Icahn School of Medicine at Mount SinaiFriedman Brain Institute, Icahn School of Medicine at Mount SinaiUNC Neuroscience Center, University of North CarolinaFriedman Brain Institute, Icahn School of Medicine at Mount SinaiDepartment of Genetics, University of North CarolinaDepartment of Neuroscience and Kavli Institute for Neuroscience, Yale School of MedicineDepartment of Genetics, University of North CarolinaFriedman Brain Institute, Icahn School of Medicine at Mount SinaiDepartment of Psychiatry, Yale School of MedicineFriedman Brain Institute, Icahn School of Medicine at Mount SinaiNeurogenetics Program, Department of Neurology, David Geffen School of Medicine University of CaliforniaThe cellular heterogeneity in brain obscures the identification of robust cellular regulatory networks. Here the authors integrate genome-wide chromosome conformation data from sorted neurons and glia, with transcriptomic and enhancer profiles, to characterize cell-type-specific gene regulatory landscapes in the human brain, and provide insights into cell-type-specific gene regulatory networks in brain disorders.https://doi.org/10.1038/s41467-021-24243-0 |
| spellingShingle | Benxia Hu Hyejung Won Won Mah Royce B. Park Bibi Kassim Keeley Spiess Alexey Kozlenkov Cheynna A. Crowley Sirisha Pochareddy The PsychENCODE Consortium Yun Li Stella Dracheva Nenad Sestan Schahram Akbarian Daniel H. Geschwind Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders Nature Communications |
| title | Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders |
| title_full | Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders |
| title_fullStr | Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders |
| title_full_unstemmed | Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders |
| title_short | Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders |
| title_sort | neuronal and glial 3d chromatin architecture informs the cellular etiology of brain disorders |
| url | https://doi.org/10.1038/s41467-021-24243-0 |
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