Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020)
The systemic immunity-inflammation index (SII) is a novel inflammatory marker, and aberrant blood lipid levels are linked to inflammation. This study aimed to look at the probable link between SII and hyperlipidemia. The current cross-sectional investigation was carried out among people with complet...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/15/5/1177 |
| _version_ | 1797614659990192128 |
|---|---|
| author | Nayili Mahemuti Xiyue Jing Naijian Zhang Chuanlang Liu Changping Li Zhuang Cui Yuanyuan Liu Jiageng Chen |
| author_facet | Nayili Mahemuti Xiyue Jing Naijian Zhang Chuanlang Liu Changping Li Zhuang Cui Yuanyuan Liu Jiageng Chen |
| author_sort | Nayili Mahemuti |
| collection | DOAJ |
| description | The systemic immunity-inflammation index (SII) is a novel inflammatory marker, and aberrant blood lipid levels are linked to inflammation. This study aimed to look at the probable link between SII and hyperlipidemia. The current cross-sectional investigation was carried out among people with complete SII and hyperlipidemia data from the 2015–2020 National Health and Nutrition Examination Survey (NHANES). SII was computed by dividing the platelet count × the neutrophil count/the lymphocyte count. The National Cholesterol Education Program standards were used to define hyperlipidemia. The nonlinear association between SII and hyperlipidemia was described using fitted smoothing curves and threshold effect analyses. A total of 6117 US adults were included in our study. A substantial positive correlation between SII and hyperlipidemia was found [1.03 (1.01, 1.05)] in a multivariate linear regression analysis. Age, sex, body mass index, smoking status, hypertension, and diabetes were not significantly correlated with this positive connection, according to subgroup analysis and interaction testing (<i>p</i> for interaction > 0.05). Additionally, we discovered a non-linear association between SII and hyperlipidemia with an inflection point of 479.15 using a two-segment linear regression model. Our findings suggest a significant association between SII levels and hyperlipidemia. More large-scale prospective studies are needed to investigate the role of SII in hyperlipidemia. |
| first_indexed | 2024-03-11T07:14:32Z |
| format | Article |
| id | doaj.art-58d5a24fe6c842f3a074dccb81590d3a |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T07:14:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-58d5a24fe6c842f3a074dccb81590d3a2023-11-17T08:20:40ZengMDPI AGNutrients2072-66432023-02-01155117710.3390/nu15051177Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020)Nayili Mahemuti0Xiyue Jing1Naijian Zhang2Chuanlang Liu3Changping Li4Zhuang Cui5Yuanyuan Liu6Jiageng Chen7School of Public Health, Tianjin Medical University, Tianjin 300070, ChinaTianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Neurosurgical Institute, Tianjin Huanhu Hospital, Tianjin 300070, ChinaSchool of Public Health, Tianjin Medical University, Tianjin 300070, ChinaSchool of Public Health, Tianjin Medical University, Tianjin 300070, ChinaSchool of Public Health, Tianjin Medical University, Tianjin 300070, ChinaSchool of Public Health, Tianjin Medical University, Tianjin 300070, ChinaSchool of Public Health, Tianjin Medical University, Tianjin 300070, ChinaSchool of Public Health, Tianjin Medical University, Tianjin 300070, ChinaThe systemic immunity-inflammation index (SII) is a novel inflammatory marker, and aberrant blood lipid levels are linked to inflammation. This study aimed to look at the probable link between SII and hyperlipidemia. The current cross-sectional investigation was carried out among people with complete SII and hyperlipidemia data from the 2015–2020 National Health and Nutrition Examination Survey (NHANES). SII was computed by dividing the platelet count × the neutrophil count/the lymphocyte count. The National Cholesterol Education Program standards were used to define hyperlipidemia. The nonlinear association between SII and hyperlipidemia was described using fitted smoothing curves and threshold effect analyses. A total of 6117 US adults were included in our study. A substantial positive correlation between SII and hyperlipidemia was found [1.03 (1.01, 1.05)] in a multivariate linear regression analysis. Age, sex, body mass index, smoking status, hypertension, and diabetes were not significantly correlated with this positive connection, according to subgroup analysis and interaction testing (<i>p</i> for interaction > 0.05). Additionally, we discovered a non-linear association between SII and hyperlipidemia with an inflection point of 479.15 using a two-segment linear regression model. Our findings suggest a significant association between SII levels and hyperlipidemia. More large-scale prospective studies are needed to investigate the role of SII in hyperlipidemia.https://www.mdpi.com/2072-6643/15/5/1177systemic immunity-inflammation indexhyperlipidemiacross-sectional studyNHANES |
| spellingShingle | Nayili Mahemuti Xiyue Jing Naijian Zhang Chuanlang Liu Changping Li Zhuang Cui Yuanyuan Liu Jiageng Chen Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020) Nutrients systemic immunity-inflammation index hyperlipidemia cross-sectional study NHANES |
| title | Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020) |
| title_full | Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020) |
| title_fullStr | Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020) |
| title_full_unstemmed | Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020) |
| title_short | Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015–2020) |
| title_sort | association between systemic immunity inflammation index and hyperlipidemia a population based study from the nhanes 2015 2020 |
| topic | systemic immunity-inflammation index hyperlipidemia cross-sectional study NHANES |
| url | https://www.mdpi.com/2072-6643/15/5/1177 |
| work_keys_str_mv | AT nayilimahemuti associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT xiyuejing associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT naijianzhang associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT chuanlangliu associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT changpingli associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT zhuangcui associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT yuanyuanliu associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 AT jiagengchen associationbetweensystemicimmunityinflammationindexandhyperlipidemiaapopulationbasedstudyfromthenhanes20152020 |