Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance
<p>Abstract</p> <p>Background</p> <p>A randomized control trial was performed to test whether a lifestyle intervention program, carried out in a primary healthcare setting using existing resources, can reduce the incidence of type 2 diabetes in Japanese with impaired gl...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-01-01
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| Series: | BMC Public Health |
| Online Access: | http://www.biomedcentral.com/1471-2458/11/40 |
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| author | Usui Takeshi Sato Yuzo Kawazu Shoji Tominaga Makoto Tsuzaki Kokoro Kotani Kazuhiko Tsujii Satoru Tsushita Kazuyo Sato Juichi Sakane Naoki Kamae Isao Yoshida Toshihide Kiyohara Yutaka Sato Shigeaki Kuzuya Hideshi |
| author_facet | Usui Takeshi Sato Yuzo Kawazu Shoji Tominaga Makoto Tsuzaki Kokoro Kotani Kazuhiko Tsujii Satoru Tsushita Kazuyo Sato Juichi Sakane Naoki Kamae Isao Yoshida Toshihide Kiyohara Yutaka Sato Shigeaki Kuzuya Hideshi |
| author_sort | Usui Takeshi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>A randomized control trial was performed to test whether a lifestyle intervention program, carried out in a primary healthcare setting using existing resources, can reduce the incidence of type 2 diabetes in Japanese with impaired glucose tolerance (IGT). The results of 3 years' intervention are summarized.</p> <p>Methods</p> <p>Through health checkups in communities and workplaces, 304 middle-aged IGT subjects with a mean body mass index (BMI) of 24.5 kg/m<sup>2 </sup>were recruited and randomized to the intervention group or control group. The lifestyle intervention was carried out for 3 years by public health nurses using the curriculum and educational materials provided by the study group.</p> <p>Results</p> <p>After 1 year, the intervention had significantly improved body weight (-1.5 ± 0.7 vs. -0.7 ± 2.5 kg in the control; p = 0.023) and daily non-exercise leisure time energy expenditure (25 ± 113 vs. -3 ± 98 kcal; p = 0.045). Insulin sensitivity assessed by the Matsuda index was improved by the intervention during the 3 years. The 3-year cumulative incidence tended to be lower in the intervention group (14.8% vs.8.2%, log-rank test: p = 0.097). In a sub-analysis for the subjects with a BMI > 22.5 kg/m<sup>2</sup>, a significant reduction in the cumulative incidence was found (p = 0.027).</p> <p>Conclusions</p> <p>The present lifestyle intervention program using existing healthcare resources is beneficial in preventing diabetes in Japanese with IGT. This has important implications for primary healthcare-based diabetes prevention.</p> <p>Trial registration number</p> <p><b>UMIN000003136</b></p> |
| first_indexed | 2024-12-20T00:54:13Z |
| format | Article |
| id | doaj.art-58d78cb2593848d4bf4564e0308da24c |
| institution | Directory Open Access Journal |
| issn | 1471-2458 |
| language | English |
| last_indexed | 2024-12-20T00:54:13Z |
| publishDate | 2011-01-01 |
| publisher | BMC |
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| spelling | doaj.art-58d78cb2593848d4bf4564e0308da24c2022-12-21T19:59:09ZengBMCBMC Public Health1471-24582011-01-011114010.1186/1471-2458-11-40Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose toleranceUsui TakeshiSato YuzoKawazu ShojiTominaga MakotoTsuzaki KokoroKotani KazuhikoTsujii SatoruTsushita KazuyoSato JuichiSakane NaokiKamae IsaoYoshida ToshihideKiyohara YutakaSato ShigeakiKuzuya Hideshi<p>Abstract</p> <p>Background</p> <p>A randomized control trial was performed to test whether a lifestyle intervention program, carried out in a primary healthcare setting using existing resources, can reduce the incidence of type 2 diabetes in Japanese with impaired glucose tolerance (IGT). The results of 3 years' intervention are summarized.</p> <p>Methods</p> <p>Through health checkups in communities and workplaces, 304 middle-aged IGT subjects with a mean body mass index (BMI) of 24.5 kg/m<sup>2 </sup>were recruited and randomized to the intervention group or control group. The lifestyle intervention was carried out for 3 years by public health nurses using the curriculum and educational materials provided by the study group.</p> <p>Results</p> <p>After 1 year, the intervention had significantly improved body weight (-1.5 ± 0.7 vs. -0.7 ± 2.5 kg in the control; p = 0.023) and daily non-exercise leisure time energy expenditure (25 ± 113 vs. -3 ± 98 kcal; p = 0.045). Insulin sensitivity assessed by the Matsuda index was improved by the intervention during the 3 years. The 3-year cumulative incidence tended to be lower in the intervention group (14.8% vs.8.2%, log-rank test: p = 0.097). In a sub-analysis for the subjects with a BMI > 22.5 kg/m<sup>2</sup>, a significant reduction in the cumulative incidence was found (p = 0.027).</p> <p>Conclusions</p> <p>The present lifestyle intervention program using existing healthcare resources is beneficial in preventing diabetes in Japanese with IGT. This has important implications for primary healthcare-based diabetes prevention.</p> <p>Trial registration number</p> <p><b>UMIN000003136</b></p>http://www.biomedcentral.com/1471-2458/11/40 |
| spellingShingle | Usui Takeshi Sato Yuzo Kawazu Shoji Tominaga Makoto Tsuzaki Kokoro Kotani Kazuhiko Tsujii Satoru Tsushita Kazuyo Sato Juichi Sakane Naoki Kamae Isao Yoshida Toshihide Kiyohara Yutaka Sato Shigeaki Kuzuya Hideshi Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance BMC Public Health |
| title | Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance |
| title_full | Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance |
| title_fullStr | Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance |
| title_full_unstemmed | Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance |
| title_short | Prevention of type 2 diabetes in a primary healthcare setting: Three-year results of lifestyle intervention in Japanese subjects with impaired glucose tolerance |
| title_sort | prevention of type 2 diabetes in a primary healthcare setting three year results of lifestyle intervention in japanese subjects with impaired glucose tolerance |
| url | http://www.biomedcentral.com/1471-2458/11/40 |
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