SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY
ABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulti...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Coluna (SBC)
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| Series: | Coluna/Columna |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000100067&lng=en&tlng=en |
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| author | MARCO ANTONIO EDUARDO KOFF LUKMAN OLALEKAN AJIBOYE NATÁLIA DIEL LISBOA ASDRUBAL FALAVIGNA |
| author_facet | MARCO ANTONIO EDUARDO KOFF LUKMAN OLALEKAN AJIBOYE NATÁLIA DIEL LISBOA ASDRUBAL FALAVIGNA |
| author_sort | MARCO ANTONIO EDUARDO KOFF |
| collection | DOAJ |
| description | ABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulting in 686 articles. Studies of non-traumatic injuries, non-antioxidant therapies, absence of neurological and functional evaluation, and non-experimental studies were excluded, leaving a total of 43 articles. The most used therapies were melatonin (16.2%), quercetin (9.3%), epigallocatechin and edaravone (6.9%). The most frequent route of administration was intraperitoneal (72.09%). The dose and mode of administration varied greatly, with a single dose being the most commonly used (39.53%). The time elapsed from trauma to treatment was 0-15 minutes (41.8%), 15-60 minutes (30%) and over 60 minutes (10.6%). Histological analysis was performed in 32 studies (74.41%). The BBB scale was the main functional measure applied (55.8%), followed by the inclined plane test (16.2%) and the Tarlov scale (13.9%). Positive outcomes were observed in 37 studies (86.04%). The heterogeneity of antioxidant therapy, with different types, doses, and measurements observed, limits the comparison of efficacy. Standardized protocols are required to make clinical translation possible. |
| first_indexed | 2024-12-12T04:53:10Z |
| format | Article |
| id | doaj.art-58dd81092f2e47a590fad49d03191675 |
| institution | Directory Open Access Journal |
| issn | 2177-014X |
| language | English |
| last_indexed | 2024-12-12T04:53:10Z |
| publisher | Sociedade Brasileira de Coluna (SBC) |
| record_format | Article |
| series | Coluna/Columna |
| spelling | doaj.art-58dd81092f2e47a590fad49d031916752022-12-22T00:37:26ZengSociedade Brasileira de Coluna (SBC)Coluna/Columna2177-014X161677310.1590/s1808-1851201716011171639S1808-18512017000100067SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPYMARCO ANTONIO EDUARDO KOFFLUKMAN OLALEKAN AJIBOYENATÁLIA DIEL LISBOAASDRUBAL FALAVIGNAABSTRACT The objective of the paper is to analyze the frequency and efficacy of experimental studies with antioxidant therapy. A search was conducted in the pubmed.gov database using the keywords "antioxidants" AND "spinal cord injury", from January 2000 to December 2015, resulting in 686 articles. Studies of non-traumatic injuries, non-antioxidant therapies, absence of neurological and functional evaluation, and non-experimental studies were excluded, leaving a total of 43 articles. The most used therapies were melatonin (16.2%), quercetin (9.3%), epigallocatechin and edaravone (6.9%). The most frequent route of administration was intraperitoneal (72.09%). The dose and mode of administration varied greatly, with a single dose being the most commonly used (39.53%). The time elapsed from trauma to treatment was 0-15 minutes (41.8%), 15-60 minutes (30%) and over 60 minutes (10.6%). Histological analysis was performed in 32 studies (74.41%). The BBB scale was the main functional measure applied (55.8%), followed by the inclined plane test (16.2%) and the Tarlov scale (13.9%). Positive outcomes were observed in 37 studies (86.04%). The heterogeneity of antioxidant therapy, with different types, doses, and measurements observed, limits the comparison of efficacy. Standardized protocols are required to make clinical translation possible.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000100067&lng=en&tlng=enAntioxidantsSpinal cord injuriesNeurologyNeurosurgeryReview |
| spellingShingle | MARCO ANTONIO EDUARDO KOFF LUKMAN OLALEKAN AJIBOYE NATÁLIA DIEL LISBOA ASDRUBAL FALAVIGNA SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY Coluna/Columna Antioxidants Spinal cord injuries Neurology Neurosurgery Review |
| title | SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY |
| title_full | SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY |
| title_fullStr | SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY |
| title_full_unstemmed | SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY |
| title_short | SYSTEMATIC REVIEW OF RECOVERY OF SPINAL CORD INJURY WITH ANTIOXIDANT THERAPY |
| title_sort | systematic review of recovery of spinal cord injury with antioxidant therapy |
| topic | Antioxidants Spinal cord injuries Neurology Neurosurgery Review |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1808-18512017000100067&lng=en&tlng=en |
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