Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes
A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Slovenian Chemical Society
2022-09-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/7348 |
| Summary: | A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimized using cyclic voltammetry, showing an irreversible anodic peak in Britton-Robinson buffered medium (pH 6) at 0.86–0.90 V. The electrochemical responses were linearly correlated with alfuzosin concentrations (R2> 0.999) in the ranges of 0.6–20 and 0.3–20 μM, exhibiting higher electrocatalytic activity at PGE with a low detection limit/ detectability of 0.099 μM. In addition, this study was a successful attempt for the drug determination in tablets and spiked urine samples with green profile evaluation, employing the National Environmental Methods Index, analytical Eco-Scale score, and Green Analytical Procedure Index. |
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| ISSN: | 1318-0207 1580-3155 |