Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes
A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Slovenian Chemical Society
2022-09-01
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| Series: | Acta Chimica Slovenica |
| Subjects: | |
| Online Access: | https://journals.matheo.si/index.php/ACSi/article/view/7348 |
| _version_ | 1797962864790601728 |
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| author | Youstina Mekhail Metias Emad Mohamed Hussien Mervat Mohamed Hosny Magda Mohamed Ayad |
| author_facet | Youstina Mekhail Metias Emad Mohamed Hussien Mervat Mohamed Hosny Magda Mohamed Ayad |
| author_sort | Youstina Mekhail Metias |
| collection | DOAJ |
| description | A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimized using cyclic voltammetry, showing an irreversible anodic peak in Britton-Robinson buffered medium (pH 6) at 0.86–0.90 V. The electrochemical responses were linearly correlated with alfuzosin concentrations (R2> 0.999) in the ranges of 0.6–20 and 0.3–20 μM, exhibiting higher electrocatalytic activity at PGE with a low detection limit/ detectability of 0.099 μM. In addition, this study was a successful attempt for the drug determination in tablets and spiked urine samples with green profile evaluation, employing the National Environmental Methods Index, analytical Eco-Scale score, and Green Analytical Procedure Index. |
| first_indexed | 2024-04-11T01:20:30Z |
| format | Article |
| id | doaj.art-58e077bbadbe47399e5290f809da93b2 |
| institution | Directory Open Access Journal |
| issn | 1318-0207 1580-3155 |
| language | English |
| last_indexed | 2024-04-11T01:20:30Z |
| publishDate | 2022-09-01 |
| publisher | Slovenian Chemical Society |
| record_format | Article |
| series | Acta Chimica Slovenica |
| spelling | doaj.art-58e077bbadbe47399e5290f809da93b22023-01-03T11:29:15ZengSlovenian Chemical SocietyActa Chimica Slovenica1318-02071580-31552022-09-0169350751810.17344/acsi.2022.73481099Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodesYoustina Mekhail Metias0Emad Mohamed Hussien1Mervat Mohamed Hosny2Magda Mohamed Ayad3Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University 44519, Zagazig, Egypt.Department of Pharmaceutical Chemistry, National Organization for Drug Control and Research (NODCAR), Giza, Egypt.Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University 44519, Zagazig, Egypt.Department of Analytical Chemistry, Faculty of Pharmacy, Zagazig University 44519, Zagazig, Egypt.A sensitive and inexpensive differential pulse voltammetric technique was applied to investigate the electrochemical behavior of alfuzosin hydrochloride at two different working electrodes: silica gel modified carbon paste and pencil graphite electrodes (PGE). The voltammetric conditions were optimized using cyclic voltammetry, showing an irreversible anodic peak in Britton-Robinson buffered medium (pH 6) at 0.86–0.90 V. The electrochemical responses were linearly correlated with alfuzosin concentrations (R2> 0.999) in the ranges of 0.6–20 and 0.3–20 μM, exhibiting higher electrocatalytic activity at PGE with a low detection limit/ detectability of 0.099 μM. In addition, this study was a successful attempt for the drug determination in tablets and spiked urine samples with green profile evaluation, employing the National Environmental Methods Index, analytical Eco-Scale score, and Green Analytical Procedure Index.https://journals.matheo.si/index.php/ACSi/article/view/7348alfuzosin hydrochloridecarbon paste electrodecyclic voltammetrydifferential pulse voltammetrypencil graphite electrode |
| spellingShingle | Youstina Mekhail Metias Emad Mohamed Hussien Mervat Mohamed Hosny Magda Mohamed Ayad Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes Acta Chimica Slovenica alfuzosin hydrochloride carbon paste electrode cyclic voltammetry differential pulse voltammetry pencil graphite electrode |
| title | Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes |
| title_full | Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes |
| title_fullStr | Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes |
| title_full_unstemmed | Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes |
| title_short | Development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes |
| title_sort | development of green differential pulse voltammetric strategy for the determination of alfuzosin hydrochloride at pencil graphite and modified carbon paste electrodes |
| topic | alfuzosin hydrochloride carbon paste electrode cyclic voltammetry differential pulse voltammetry pencil graphite electrode |
| url | https://journals.matheo.si/index.php/ACSi/article/view/7348 |
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