Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19
Background: Coronavirus disease 2019 (COVID-19) has been an emerging, rapidly evolving situation in China since late 2019 and has even become a worldwide pandemic. The first case of severe childhood novel coronavirus pneumonia in China was reported in March 2020 in Wuhan. The severity differs betwee...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/5/638 |
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| author | Xiao-Ping Liu Ying-Hsien Huang Yuh-Chyn Tsai Shih-Feng Liu Ho-Chang Kuo |
| author_facet | Xiao-Ping Liu Ying-Hsien Huang Yuh-Chyn Tsai Shih-Feng Liu Ho-Chang Kuo |
| author_sort | Xiao-Ping Liu |
| collection | DOAJ |
| description | Background: Coronavirus disease 2019 (COVID-19) has been an emerging, rapidly evolving situation in China since late 2019 and has even become a worldwide pandemic. The first case of severe childhood novel coronavirus pneumonia in China was reported in March 2020 in Wuhan. The severity differs between adults and children, with lower death rates and decreased severity for individuals under the age of 20 years. Increased cases of Kawasaki disease (KD) have been reported from New York City and some areas of Italy and the U.K., with almost a 6–10 times increase when compared to previous years. We conducted this study to compare characteristics and laboratory data between KD and COVID-19 in children. Methods: We obtained a total of 24 children with COVID-19 from a literature review and 268 KD cases from our hospital via retrospective chart review. Results: We found that patients with KD have higher levels of white blood cells (WBCs), platelets, neutrophil percentage, C-reactive protein (CRP), procalcitonin, and aspartate aminotransferase (AST) and a higher body temperature, while patients with COVID-19 have a higher age, hemoglobin levels, and lymphocyte percentage. After performing multiple logistic regression analysis, we found that age, WBCs, platelets, procalcitonin, and AST are identical markers for distinguishing COVID-19 from KD in children. Conclusion: In this COVID-19 pandemic period, clinicians should pay attention to children with COVID-19 infection when high WBC, platelet, procalcitonin, and AST values are present in order to provide early diagnosis for KD or multisystem inflammatory syndrome in children (MIS-C). |
| first_indexed | 2024-03-10T03:08:36Z |
| format | Article |
| id | doaj.art-58e2253c9e5f40df8749f81e8838bf3e |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T03:08:36Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-58e2253c9e5f40df8749f81e8838bf3e2023-11-23T10:30:11ZengMDPI AGChildren2227-90672022-04-019563810.3390/children9050638Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19Xiao-Ping Liu0Ying-Hsien Huang1Yuh-Chyn Tsai2Shih-Feng Liu3Ho-Chang Kuo4The Department of Emergency and Pediatrics, Shenzhen Baoan Women’s and Children’s Hospital, Jinan University, Shenzhen 518102, ChinaKawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanDepartment of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 83301, TaiwanDepartment of Respiratory Therapy, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Kaohsiung 83301, TaiwanKawasaki Disease Center and Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, TaiwanBackground: Coronavirus disease 2019 (COVID-19) has been an emerging, rapidly evolving situation in China since late 2019 and has even become a worldwide pandemic. The first case of severe childhood novel coronavirus pneumonia in China was reported in March 2020 in Wuhan. The severity differs between adults and children, with lower death rates and decreased severity for individuals under the age of 20 years. Increased cases of Kawasaki disease (KD) have been reported from New York City and some areas of Italy and the U.K., with almost a 6–10 times increase when compared to previous years. We conducted this study to compare characteristics and laboratory data between KD and COVID-19 in children. Methods: We obtained a total of 24 children with COVID-19 from a literature review and 268 KD cases from our hospital via retrospective chart review. Results: We found that patients with KD have higher levels of white blood cells (WBCs), platelets, neutrophil percentage, C-reactive protein (CRP), procalcitonin, and aspartate aminotransferase (AST) and a higher body temperature, while patients with COVID-19 have a higher age, hemoglobin levels, and lymphocyte percentage. After performing multiple logistic regression analysis, we found that age, WBCs, platelets, procalcitonin, and AST are identical markers for distinguishing COVID-19 from KD in children. Conclusion: In this COVID-19 pandemic period, clinicians should pay attention to children with COVID-19 infection when high WBC, platelet, procalcitonin, and AST values are present in order to provide early diagnosis for KD or multisystem inflammatory syndrome in children (MIS-C).https://www.mdpi.com/2227-9067/9/5/638childhoodCOVID-19Kawasaki diseaseKawasaki-like diseasemultisystem inflammatory syndrome in children (MIS-C) |
| spellingShingle | Xiao-Ping Liu Ying-Hsien Huang Yuh-Chyn Tsai Shih-Feng Liu Ho-Chang Kuo Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19 Children childhood COVID-19 Kawasaki disease Kawasaki-like disease multisystem inflammatory syndrome in children (MIS-C) |
| title | Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19 |
| title_full | Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19 |
| title_fullStr | Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19 |
| title_full_unstemmed | Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19 |
| title_short | Comparison of Laboratory Data between Children with Kawasaki Disease and COVID-19 |
| title_sort | comparison of laboratory data between children with kawasaki disease and covid 19 |
| topic | childhood COVID-19 Kawasaki disease Kawasaki-like disease multisystem inflammatory syndrome in children (MIS-C) |
| url | https://www.mdpi.com/2227-9067/9/5/638 |
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