Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players
Introduction: Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and i...
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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Frontiers Media S.A.
2021-12-01
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| Σειρά: | Frontiers in Molecular Biosciences |
| Θέματα: | |
| Διαθέσιμο Online: | https://www.frontiersin.org/articles/10.3389/fmolb.2021.727144/full |
| _version_ | 1831716965663637504 |
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| author | Shamma Al-Muraikhy Shamma Al-Muraikhy Maha Sellami Alexander S Domling Najeha Rizwana Abdelali Agouni Abdelali Agouni Fatima Al-Khelaifi Francesco Donati Francesco Botre Ilhame Diboun Mohamed A Elrayess Mohamed A Elrayess |
| author_facet | Shamma Al-Muraikhy Shamma Al-Muraikhy Maha Sellami Alexander S Domling Najeha Rizwana Abdelali Agouni Abdelali Agouni Fatima Al-Khelaifi Francesco Donati Francesco Botre Ilhame Diboun Mohamed A Elrayess Mohamed A Elrayess |
| author_sort | Shamma Al-Muraikhy |
| collection | DOAJ |
| description | Introduction: Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players.Methods: Levels of 837 blood metabolites and LTL were measured in 126 young elite male soccer players who tested negative for doping abuse at anti-doping laboratory in Italy. Multivariate analysis using orthogonal partial least squares (OPLS), univariate linear models and enrichment analyses were conducted to identify metabolites and metabolic pathways associated with LTL. Generalized linear model followed by receiver operating characteristic (ROC) analysis were conducted to identify top metabolites predictive of LTL.Results: Sixty-seven metabolites and seven metabolic pathways showed significant associations with LTL. Among enriched pathways, lysophospholipids, benzoate metabolites, and glycine/serine/threonine metabolites were elevated with longer LTL. Conversely, monoacylglycerols, sphingolipid metabolites, long chain fatty acids and polyunsaturated fatty acids were enriched with shorter telomeres. ROC analysis revealed eight metabolites that best predict LTL, including glutamine, N-acetylglutamine, xanthine, beta-sitosterol, N2-acetyllysine, stearoyl-arachidonoyl-glycerol (18:0/20:4), N-acetylserine and 3-7-dimethylurate with AUC of 0.75 (0.64–0.87, p < 0.0001).Conclusion: This study characterized the metabolic activity in relation to telomere length in elite soccer players. Investigating the functional relevance of these associations could provide a better understanding of exercise physiology and pathophysiology of elite athletes. |
| first_indexed | 2024-12-21T00:49:59Z |
| format | Article |
| id | doaj.art-58e2f1aec2d74f5cb6f561367a19b60c |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-12-21T00:49:59Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-58e2f1aec2d74f5cb6f561367a19b60c2022-12-21T19:21:25ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2021-12-01810.3389/fmolb.2021.727144727144Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer PlayersShamma Al-Muraikhy0Shamma Al-Muraikhy1Maha Sellami2Alexander S Domling3Najeha Rizwana4Abdelali Agouni5Abdelali Agouni6Fatima Al-Khelaifi7Francesco Donati8Francesco Botre9Ilhame Diboun10Mohamed A Elrayess11Mohamed A Elrayess12Biomedical Research Center, Qatar University, Doha, QatarDepartment of Drug Design, University of Groningen, Groningen, NetherlandsDepartment of Physical Education (PE), College of Education, Qatar University, Doha, QatarDepartment of Drug Design, University of Groningen, Groningen, NetherlandsBiomedical Research Center, Qatar University, Doha, QatarDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha, QatarBiomedical and Pharmaceutical Research Unit (BPRU), QU Health, Qatar University, Doha, QatarAnti-Doping Lab Qatar, Doha, QatarLaboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, ItalyLaboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, ItalyCollege of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Doha, QatarBiomedical Research Center, Qatar University, Doha, QatarBiomedical and Pharmaceutical Research Unit (BPRU), QU Health, Qatar University, Doha, QatarIntroduction: Biological aging is associated with changes in the metabolic pathways. Leukocyte telomere length (LTL) is a predictive marker of biological aging; however, the underlying metabolic pathways remain largely unknown. The aim of this study was to investigate the metabolic alterations and identify the metabolic predictors of LTL in elite male soccer players.Methods: Levels of 837 blood metabolites and LTL were measured in 126 young elite male soccer players who tested negative for doping abuse at anti-doping laboratory in Italy. Multivariate analysis using orthogonal partial least squares (OPLS), univariate linear models and enrichment analyses were conducted to identify metabolites and metabolic pathways associated with LTL. Generalized linear model followed by receiver operating characteristic (ROC) analysis were conducted to identify top metabolites predictive of LTL.Results: Sixty-seven metabolites and seven metabolic pathways showed significant associations with LTL. Among enriched pathways, lysophospholipids, benzoate metabolites, and glycine/serine/threonine metabolites were elevated with longer LTL. Conversely, monoacylglycerols, sphingolipid metabolites, long chain fatty acids and polyunsaturated fatty acids were enriched with shorter telomeres. ROC analysis revealed eight metabolites that best predict LTL, including glutamine, N-acetylglutamine, xanthine, beta-sitosterol, N2-acetyllysine, stearoyl-arachidonoyl-glycerol (18:0/20:4), N-acetylserine and 3-7-dimethylurate with AUC of 0.75 (0.64–0.87, p < 0.0001).Conclusion: This study characterized the metabolic activity in relation to telomere length in elite soccer players. Investigating the functional relevance of these associations could provide a better understanding of exercise physiology and pathophysiology of elite athletes.https://www.frontiersin.org/articles/10.3389/fmolb.2021.727144/fulltelomere lengthelite athletessocceragingmetabolomics |
| spellingShingle | Shamma Al-Muraikhy Shamma Al-Muraikhy Maha Sellami Alexander S Domling Najeha Rizwana Abdelali Agouni Abdelali Agouni Fatima Al-Khelaifi Francesco Donati Francesco Botre Ilhame Diboun Mohamed A Elrayess Mohamed A Elrayess Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players Frontiers in Molecular Biosciences telomere length elite athletes soccer aging metabolomics |
| title | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_full | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_fullStr | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_full_unstemmed | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_short | Metabolic Signature of Leukocyte Telomere Length in Elite Male Soccer Players |
| title_sort | metabolic signature of leukocyte telomere length in elite male soccer players |
| topic | telomere length elite athletes soccer aging metabolomics |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2021.727144/full |
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