Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease
Studies using animal models have shed light into the molecular and cellular basis for the neuropathology observed in patients with Alzheimer’s disease (AD). In particular, the role of the amyloid precursor protein (APP) plays a crucial role in the formation of senile plaques and aging-dependent dege...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/13/7022 |
| _version_ | 1797411420827025408 |
|---|---|
| author | David Jalali Justine Anne Guevarra Luz Martinez Lily Hung Fernando J Vonhoff |
| author_facet | David Jalali Justine Anne Guevarra Luz Martinez Lily Hung Fernando J Vonhoff |
| author_sort | David Jalali |
| collection | DOAJ |
| description | Studies using animal models have shed light into the molecular and cellular basis for the neuropathology observed in patients with Alzheimer’s disease (AD). In particular, the role of the amyloid precursor protein (APP) plays a crucial role in the formation of senile plaques and aging-dependent degeneration. Here, we focus our review on recent findings using the <i>Drosophila</i> AD model to expand our understanding of APP molecular function and interactions, including insights gained from the fly homolog APP-like (APPL). Finally, as there is still no cure for AD, we review some approaches that have shown promising results in ameliorating AD-associated phenotypes, with special attention on the use of nutraceuticals and their molecular effects, as well as interactions with the gut microbiome. Overall, the phenomena described here are of fundamental significance for understanding network development and degeneration. Given the highly conserved nature of fundamental signaling pathways, the insight gained from animal models such as <i>Drosophila melanogaster</i> will likely advance the understanding of the mammalian brain, and thus be relevant to human health. |
| first_indexed | 2024-03-09T04:45:53Z |
| format | Article |
| id | doaj.art-58e56f3755a741cda20d1a4a6fba9f6f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:45:53Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-58e56f3755a741cda20d1a4a6fba9f6f2023-12-03T13:15:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213702210.3390/ijms22137022Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s DiseaseDavid Jalali0Justine Anne Guevarra1Luz Martinez2Lily Hung3Fernando J Vonhoff4Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USADepartment of Biological Sciences, Towson University, Towson, MD 21252, USADepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USADepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USADepartment of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USAStudies using animal models have shed light into the molecular and cellular basis for the neuropathology observed in patients with Alzheimer’s disease (AD). In particular, the role of the amyloid precursor protein (APP) plays a crucial role in the formation of senile plaques and aging-dependent degeneration. Here, we focus our review on recent findings using the <i>Drosophila</i> AD model to expand our understanding of APP molecular function and interactions, including insights gained from the fly homolog APP-like (APPL). Finally, as there is still no cure for AD, we review some approaches that have shown promising results in ameliorating AD-associated phenotypes, with special attention on the use of nutraceuticals and their molecular effects, as well as interactions with the gut microbiome. Overall, the phenomena described here are of fundamental significance for understanding network development and degeneration. Given the highly conserved nature of fundamental signaling pathways, the insight gained from animal models such as <i>Drosophila melanogaster</i> will likely advance the understanding of the mammalian brain, and thus be relevant to human health.https://www.mdpi.com/1422-0067/22/13/7022nutritionneurodegenerationgut microbiomeinsect disease models |
| spellingShingle | David Jalali Justine Anne Guevarra Luz Martinez Lily Hung Fernando J Vonhoff Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease International Journal of Molecular Sciences nutrition neurodegeneration gut microbiome insect disease models |
| title | Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease |
| title_full | Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease |
| title_fullStr | Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease |
| title_full_unstemmed | Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease |
| title_short | Nutraceutical and Probiotic Approaches to Examine Molecular Interactions of the Amyloid Precursor Protein APP in <i>Drosophila</i> Models of Alzheimer’s Disease |
| title_sort | nutraceutical and probiotic approaches to examine molecular interactions of the amyloid precursor protein app in i drosophila i models of alzheimer s disease |
| topic | nutrition neurodegeneration gut microbiome insect disease models |
| url | https://www.mdpi.com/1422-0067/22/13/7022 |
| work_keys_str_mv | AT davidjalali nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappinidrosophilaimodelsofalzheimersdisease AT justineanneguevarra nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappinidrosophilaimodelsofalzheimersdisease AT luzmartinez nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappinidrosophilaimodelsofalzheimersdisease AT lilyhung nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappinidrosophilaimodelsofalzheimersdisease AT fernandojvonhoff nutraceuticalandprobioticapproachestoexaminemolecularinteractionsoftheamyloidprecursorproteinappinidrosophilaimodelsofalzheimersdisease |