CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER
A complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that s...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-08-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/695 |
| _version_ | 1797198012678668288 |
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| author | L. V. Matveeva |
| author_facet | L. V. Matveeva |
| author_sort | L. V. Matveeva |
| collection | DOAJ |
| description | A complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that showed correlations with histological types of the tumors. Maximal baseline (pre-surgery) levels of interleukins (IL- 1β, IL-2, IL-4, IL-10) were found in highly differentiated adenocarcinoma, whereas IL-17, interferon (IFNγ) were more expressed in low differentiated carcinoma. TNFα levels were independent on histological type of the tumor. Following surgical treatment, serum concentrations of IL-1β, IL-2, IL-10 were found to be increased, along with decrease in IL-4, IL-17, IFNγ, TNFα. Following surgical treatment of gastric cancer, no septic complications were observed in the patients during the follow-up period. Our results indicate to usefulness of cytokine profile data in patients with gastric cancer during their treatment, taking into account a histological type of the tumor, in order to predict clinical course following surgical treatment. |
| first_indexed | 2024-03-08T05:49:37Z |
| format | Article |
| id | doaj.art-58e6f0c5cc844bd095eee18a69fc28e6 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:53:06Z |
| publishDate | 2014-08-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-58e6f0c5cc844bd095eee18a69fc28e62024-04-22T13:07:39ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-08-0116328929410.15789/1563-0625-2014-3-289-294692CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCERL. V. Matveeva0N.P. Ogarev Mordovsky State University, SaranskA complex clinical study included twenty patients with gastric cancer (tumor stage II) before and after surgical treatment, and 30 healthy volunteers, under appropriate informed consent. In patients with gastric cancer, we have revealed some changes of immunoregulatory peptides in blood serum that showed correlations with histological types of the tumors. Maximal baseline (pre-surgery) levels of interleukins (IL- 1β, IL-2, IL-4, IL-10) were found in highly differentiated adenocarcinoma, whereas IL-17, interferon (IFNγ) were more expressed in low differentiated carcinoma. TNFα levels were independent on histological type of the tumor. Following surgical treatment, serum concentrations of IL-1β, IL-2, IL-10 were found to be increased, along with decrease in IL-4, IL-17, IFNγ, TNFα. Following surgical treatment of gastric cancer, no septic complications were observed in the patients during the follow-up period. Our results indicate to usefulness of cytokine profile data in patients with gastric cancer during their treatment, taking into account a histological type of the tumor, in order to predict clinical course following surgical treatment.https://www.mimmun.ru/mimmun/article/view/695cytokinesinterleukininterferon-γgastric cancer |
| spellingShingle | L. V. Matveeva CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER Медицинская иммунология cytokines interleukin interferon-γ gastric cancer |
| title | CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER |
| title_full | CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER |
| title_fullStr | CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER |
| title_full_unstemmed | CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER |
| title_short | CHANGES OF IMMUNOREGULATORY PEPTIDES DURING SURGICAL TREATMENT OF GASTRIC CANCER |
| title_sort | changes of immunoregulatory peptides during surgical treatment of gastric cancer |
| topic | cytokines interleukin interferon-γ gastric cancer |
| url | https://www.mimmun.ru/mimmun/article/view/695 |
| work_keys_str_mv | AT lvmatveeva changesofimmunoregulatorypeptidesduringsurgicaltreatmentofgastriccancer |