Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury
Various gadolinium compounds have been proposed as contrasting agents for magnetic resonance imaging (MRI). In this study, we suggested a new synthesis method of gadolinium ferrate/trigadolinium pentairon(III) oxide nanoparticles (GF/TPO NPs). The specific surface area of gadolinium ferrate (GdFeO&l...
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| author | Dmitry V. Korolev Galina A. Shulmeyster Maria S. Istomina Natalia V. Evreinova Ilia V. Aleksandrov Aleksandr S. Krasichkov Viktor N. Postnov Michael M. Galagudza |
| author_facet | Dmitry V. Korolev Galina A. Shulmeyster Maria S. Istomina Natalia V. Evreinova Ilia V. Aleksandrov Aleksandr S. Krasichkov Viktor N. Postnov Michael M. Galagudza |
| author_sort | Dmitry V. Korolev |
| collection | DOAJ |
| description | Various gadolinium compounds have been proposed as contrasting agents for magnetic resonance imaging (MRI). In this study, we suggested a new synthesis method of gadolinium ferrate/trigadolinium pentairon(III) oxide nanoparticles (GF/TPO NPs). The specific surface area of gadolinium ferrate (GdFeO<sub>3</sub>) and trigadolinium pentairon(III) oxide (Gd<sub>3</sub>Fe<sub>5</sub>O<sub>12</sub>) nanoparticles was equal to 42 and 66 m<sup>2</sup>/g, respectively. The X-ray diffraction analysis confirmed that the synthesized substances were GdFeO<sub>3</sub> and Gd<sub>3</sub>Fe<sub>5</sub>O<sub>12</sub>. The gadolinium content in the samples was close to the theoretically calculated value. The free gadolinium content was negligible. Biodistribution of the GF/TPO NPs was studied in rats by fluorescent imaging and Fe<sup>2+</sup>/Fe<sup>3+</sup> quantification demonstrating predominant accumulation in such organs as lung, kidney, and liver. We showed in the in vivo rat model of myocardial ischemia–reperfusion injury that GF/TPO NPs are able to target the area of myocardial infarction as evidenced by the significantly greater level of fluorescence. In perspective, the use of fluorescently labeled GF/TPO NPs in multimodal imaging may provide basis for high-resolution 3D reconstruction of the infarcted heart, thereby serving as unique theranostic platform. |
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| language | English |
| last_indexed | 2024-03-10T01:09:15Z |
| publishDate | 2022-05-01 |
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| spelling | doaj.art-58e7cd8242a54fa29a77d242a89d6b4b2023-11-23T14:20:57ZengMDPI AGMaterials1996-19442022-05-011511383210.3390/ma15113832Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion InjuryDmitry V. Korolev0Galina A. Shulmeyster1Maria S. Istomina2Natalia V. Evreinova3Ilia V. Aleksandrov4Aleksandr S. Krasichkov5Viktor N. Postnov6Michael M. Galagudza7Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaInstitute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaInstitute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaInstitute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaInstitute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaDepartment of Radio Engineering Systems, Saint-Petersburg Electrotechnical University “LETI”, Saint-Petersburg 197376, RussiaInstitute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaInstitute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, RussiaVarious gadolinium compounds have been proposed as contrasting agents for magnetic resonance imaging (MRI). In this study, we suggested a new synthesis method of gadolinium ferrate/trigadolinium pentairon(III) oxide nanoparticles (GF/TPO NPs). The specific surface area of gadolinium ferrate (GdFeO<sub>3</sub>) and trigadolinium pentairon(III) oxide (Gd<sub>3</sub>Fe<sub>5</sub>O<sub>12</sub>) nanoparticles was equal to 42 and 66 m<sup>2</sup>/g, respectively. The X-ray diffraction analysis confirmed that the synthesized substances were GdFeO<sub>3</sub> and Gd<sub>3</sub>Fe<sub>5</sub>O<sub>12</sub>. The gadolinium content in the samples was close to the theoretically calculated value. The free gadolinium content was negligible. Biodistribution of the GF/TPO NPs was studied in rats by fluorescent imaging and Fe<sup>2+</sup>/Fe<sup>3+</sup> quantification demonstrating predominant accumulation in such organs as lung, kidney, and liver. We showed in the in vivo rat model of myocardial ischemia–reperfusion injury that GF/TPO NPs are able to target the area of myocardial infarction as evidenced by the significantly greater level of fluorescence. In perspective, the use of fluorescently labeled GF/TPO NPs in multimodal imaging may provide basis for high-resolution 3D reconstruction of the infarcted heart, thereby serving as unique theranostic platform.https://www.mdpi.com/1996-1944/15/11/3832nanoparticlesgadolinium ferratetrigadolinium pentairon(III) oxidefluorophoresindocyanine greenbiodistribution |
| spellingShingle | Dmitry V. Korolev Galina A. Shulmeyster Maria S. Istomina Natalia V. Evreinova Ilia V. Aleksandrov Aleksandr S. Krasichkov Viktor N. Postnov Michael M. Galagudza Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury Materials nanoparticles gadolinium ferrate trigadolinium pentairon(III) oxide fluorophores indocyanine green biodistribution |
| title | Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury |
| title_full | Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury |
| title_fullStr | Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury |
| title_full_unstemmed | Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury |
| title_short | Fluorescently Labeled Gadolinium Ferrate/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia–Reperfusion Injury |
| title_sort | fluorescently labeled gadolinium ferrate trigadolinium pentairon iii oxide nanoparticles synthesis characterization in vivo biodistribution and application for visualization of myocardial ischemia reperfusion injury |
| topic | nanoparticles gadolinium ferrate trigadolinium pentairon(III) oxide fluorophores indocyanine green biodistribution |
| url | https://www.mdpi.com/1996-1944/15/11/3832 |
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