Multidrug resistance markers in acute myeloid leukemias
Multidrug resistance (MDR) is the cell resistance to a number of drugs. Proteins from the ABC-transporter family are the most studied factors of the MDR phenomenon. According to the literature Pgp, MRP1, BCRP, and LRP are proteins involved in the development of the MDR. The authors detected the expr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-11-01
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| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/636 |
| _version_ | 1797855469258145792 |
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| author | O. D. Zakharov Ye. Yu. Rybalkina M. A. Volkova A. A. Stavrovskaya |
| author_facet | O. D. Zakharov Ye. Yu. Rybalkina M. A. Volkova A. A. Stavrovskaya |
| author_sort | O. D. Zakharov |
| collection | DOAJ |
| description | Multidrug resistance (MDR) is the cell resistance to a number of drugs. Proteins from the ABC-transporter family are the most studied factors of the MDR phenomenon. According to the literature Pgp, MRP1, BCRP, and LRP are proteins involved in the development of the MDR. The authors detected the expression of these proteins in untreated patients with acute myeloid leukemia (other than M3). Expression of these proteins was observed in 64.3%, 46.4%, 64.3%, and 42.9% of patients, respectively. In all non-responders blast cells expressed more than one marker of MDR. Expression of 3 and 4 markers was found in 80% of non-responders while in responders 1—2 markers were expressed in 83%. |
| first_indexed | 2024-04-09T20:24:12Z |
| format | Article |
| id | doaj.art-58e8aa67afe64cb086c166801d4099a3 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:24:12Z |
| publishDate | 2022-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-58e8aa67afe64cb086c166801d4099a32023-03-30T20:15:14ZrusABV-pressОнкогематология1818-83462413-40232022-11-0101-291510.17650/1818-8346-2006-0-1-2-9-15514Multidrug resistance markers in acute myeloid leukemiasO. D. Zakharov0Ye. Yu. Rybalkina1M. A. Volkova2A. A. Stavrovskaya3N.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesN.N. Blokhin Russian Cancer Research Cancer, Russian Academy of Medical SciencesMultidrug resistance (MDR) is the cell resistance to a number of drugs. Proteins from the ABC-transporter family are the most studied factors of the MDR phenomenon. According to the literature Pgp, MRP1, BCRP, and LRP are proteins involved in the development of the MDR. The authors detected the expression of these proteins in untreated patients with acute myeloid leukemia (other than M3). Expression of these proteins was observed in 64.3%, 46.4%, 64.3%, and 42.9% of patients, respectively. In all non-responders blast cells expressed more than one marker of MDR. Expression of 3 and 4 markers was found in 80% of non-responders while in responders 1—2 markers were expressed in 83%.https://oncohematology.abvpress.ru/ongm/article/view/636acute myeloid leukemiamdrpgpmrp1bcrplrp |
| spellingShingle | O. D. Zakharov Ye. Yu. Rybalkina M. A. Volkova A. A. Stavrovskaya Multidrug resistance markers in acute myeloid leukemias Онкогематология acute myeloid leukemia mdr pgp mrp1 bcrp lrp |
| title | Multidrug resistance markers in acute myeloid leukemias |
| title_full | Multidrug resistance markers in acute myeloid leukemias |
| title_fullStr | Multidrug resistance markers in acute myeloid leukemias |
| title_full_unstemmed | Multidrug resistance markers in acute myeloid leukemias |
| title_short | Multidrug resistance markers in acute myeloid leukemias |
| title_sort | multidrug resistance markers in acute myeloid leukemias |
| topic | acute myeloid leukemia mdr pgp mrp1 bcrp lrp |
| url | https://oncohematology.abvpress.ru/ongm/article/view/636 |
| work_keys_str_mv | AT odzakharov multidrugresistancemarkersinacutemyeloidleukemias AT yeyurybalkina multidrugresistancemarkersinacutemyeloidleukemias AT mavolkova multidrugresistancemarkersinacutemyeloidleukemias AT aastavrovskaya multidrugresistancemarkersinacutemyeloidleukemias |