2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate
In the title compound, C28H27BrN4O3S2·2C2H6O, the cyclohexane ring adopts a chair conformation. The imidazo[2,1-b][1,3]thiazole ring system is essentially planar with a dihedral angle of 1.1 (2)° between the thiazole and imidazole rings. The mean plane of this...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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International Union of Crystallography
2012-05-01
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| Series: | Acta Crystallographica Section E |
| Online Access: | http://scripts.iucr.org/cgi-bin/paper?S1600536812015371 |
| _version_ | 1798030788146495488 |
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| author | Sevim Türktekin-Çelikesir Nuray Ulusoy Güzeldemirci Elif Gürsoy Muhammad Nawaz Tahir Mehmet Akkurt |
| author_facet | Sevim Türktekin-Çelikesir Nuray Ulusoy Güzeldemirci Elif Gürsoy Muhammad Nawaz Tahir Mehmet Akkurt |
| author_sort | Sevim Türktekin-Çelikesir |
| collection | DOAJ |
| description | In the title compound, C28H27BrN4O3S2·2C2H6O, the cyclohexane ring adopts a chair conformation. The imidazo[2,1-b][1,3]thiazole ring system is essentially planar with a dihedral angle of 1.1 (2)° between the thiazole and imidazole rings. The mean plane of this ring system makes dihedral angles of 8.11 (16) and 79.43 (17)°, respectively, with the bromo- and hydroxy-substituted benzene rings. In the 5-methyl-1,3-thiazolidin-4-one group, the S atom, the methyl group and the ring C atoms bonded to them are disordered over two sets of sites with refined occupancies of 0.610 (19) and 0.390 (19). The crystal structure features N—H...O, O—H...O, O—H...N and C—H...O hydrogen bonds and C—H...π interactions. Furthermore, two weak π–π stacking interactions [centroid–centroid distances = 3.967 (3) and 3.892 (2) Å] are also observed. |
| first_indexed | 2024-04-11T19:45:58Z |
| format | Article |
| id | doaj.art-58e8f683b42d47d3a3b4d13f6f2a6b41 |
| institution | Directory Open Access Journal |
| issn | 1600-5368 |
| language | English |
| last_indexed | 2024-04-11T19:45:58Z |
| publishDate | 2012-05-01 |
| publisher | International Union of Crystallography |
| record_format | Article |
| series | Acta Crystallographica Section E |
| spelling | doaj.art-58e8f683b42d47d3a3b4d13f6f2a6b412022-12-22T04:06:28ZengInternational Union of CrystallographyActa Crystallographica Section E1600-53682012-05-01685o1505o150610.1107/S16005368120153712-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvateSevim Türktekin-ÇelikesirNuray Ulusoy GüzeldemirciElif GürsoyMuhammad Nawaz TahirMehmet AkkurtIn the title compound, C28H27BrN4O3S2·2C2H6O, the cyclohexane ring adopts a chair conformation. The imidazo[2,1-b][1,3]thiazole ring system is essentially planar with a dihedral angle of 1.1 (2)° between the thiazole and imidazole rings. The mean plane of this ring system makes dihedral angles of 8.11 (16) and 79.43 (17)°, respectively, with the bromo- and hydroxy-substituted benzene rings. In the 5-methyl-1,3-thiazolidin-4-one group, the S atom, the methyl group and the ring C atoms bonded to them are disordered over two sets of sites with refined occupancies of 0.610 (19) and 0.390 (19). The crystal structure features N—H...O, O—H...O, O—H...N and C—H...O hydrogen bonds and C—H...π interactions. Furthermore, two weak π–π stacking interactions [centroid–centroid distances = 3.967 (3) and 3.892 (2) Å] are also observed.http://scripts.iucr.org/cgi-bin/paper?S1600536812015371 |
| spellingShingle | Sevim Türktekin-Çelikesir Nuray Ulusoy Güzeldemirci Elif Gürsoy Muhammad Nawaz Tahir Mehmet Akkurt 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate Acta Crystallographica Section E |
| title | 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate |
| title_full | 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate |
| title_fullStr | 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate |
| title_full_unstemmed | 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate |
| title_short | 2-[6-(4-Bromophenyl)imidazo[2,1-b][1,3]thiazol-3-yl]-N-[8-(4-hydroxyphenyl)-2-methyl-3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl]acetamide ethanol disolvate |
| title_sort | 2 6 4 bromophenyl imidazo 2 1 b 1 3 thiazol 3 yl n 8 4 hydroxyphenyl 2 methyl 3 oxo 1 thia 4 azaspiro 4 5 decan 4 yl acetamide ethanol disolvate |
| url | http://scripts.iucr.org/cgi-bin/paper?S1600536812015371 |
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