Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism

Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective end joining play critical roles in the repair...

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Bibliographic Details
Main Authors: REN Junle, GUO Xiaopeng, LEI Cairong, ZHANG Miaomiao, CHAI Ran, LU Dong
Format: Article
Language:zho
Published: Science Press 2023-06-01
Series:Fushe yanjiu yu fushe gongyi xuebao
Subjects:
Online Access:http://www.fs.sinap.ac.cn/thesisDetails#10.11889/j.1000-3436.2022-0081&lang=zh
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Summary:Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective end joining play critical roles in the repair of DNA DSBs. However, the factors that affect the selection of repair pathways for DNA DSBs remain unclear. In this study, recent findings on DNA damage characteristics and repair pathways generated by heavy-ion radiation cells are reviewed, and the selection mechanism of DSB repair pathways in cells is explained in terms of the types and distribution of DNA DSBs, chromatin status, DNA terminal structures, DNA terminal excision, and cell cycles. This review is of great significance for the study of DNA damage repair and provides a reference for investigating the biological effects of heavy-ion radiation technology.
ISSN:1000-3436