Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism
Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective end joining play critical roles in the repair...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Science Press
2023-06-01
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| Series: | Fushe yanjiu yu fushe gongyi xuebao |
| Subjects: | |
| Online Access: | http://www.fs.sinap.ac.cn/thesisDetails#10.11889/j.1000-3436.2022-0081&lang=zh |
| _version_ | 1827902902780297216 |
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| author | REN Junle GUO Xiaopeng LEI Cairong ZHANG Miaomiao CHAI Ran LU Dong |
| author_facet | REN Junle GUO Xiaopeng LEI Cairong ZHANG Miaomiao CHAI Ran LU Dong |
| author_sort | REN Junle |
| collection | DOAJ |
| description | Heavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective end joining play critical roles in the repair of DNA DSBs. However, the factors that affect the selection of repair pathways for DNA DSBs remain unclear. In this study, recent findings on DNA damage characteristics and repair pathways generated by heavy-ion radiation cells are reviewed, and the selection mechanism of DSB repair pathways in cells is explained in terms of the types and distribution of DNA DSBs, chromatin status, DNA terminal structures, DNA terminal excision, and cell cycles. This review is of great significance for the study of DNA damage repair and provides a reference for investigating the biological effects of heavy-ion radiation technology. |
| first_indexed | 2024-03-13T00:05:44Z |
| format | Article |
| id | doaj.art-58ebf2563af5406c9bdb64425df4414a |
| institution | Directory Open Access Journal |
| issn | 1000-3436 |
| language | zho |
| last_indexed | 2024-03-13T00:05:44Z |
| publishDate | 2023-06-01 |
| publisher | Science Press |
| record_format | Article |
| series | Fushe yanjiu yu fushe gongyi xuebao |
| spelling | doaj.art-58ebf2563af5406c9bdb64425df4414a2023-07-13T03:05:50ZzhoScience PressFushe yanjiu yu fushe gongyi xuebao1000-34362023-06-0141303010103010110.11889/j.1000-3436.2022-00811000-3436（2023）03-0001-10Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanismREN Junle0GUO Xiaopeng1LEI Cairong2ZHANG Miaomiao3CHAI Ran4LU Dong5Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaLanzhou University of Technology, Lanzhou 730050, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaLanzhou University of Technology, Lanzhou 730050, ChinaInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, ChinaHeavy-ion beam radiation can cause cell DNA double-strand breaks (DSBs), which are factors that lead to genomic instability. Existing studies have demonstrated that homologous end joining, homologous recombination, single-strand annealing, and selective end joining play critical roles in the repair of DNA DSBs. However, the factors that affect the selection of repair pathways for DNA DSBs remain unclear. In this study, recent findings on DNA damage characteristics and repair pathways generated by heavy-ion radiation cells are reviewed, and the selection mechanism of DSB repair pathways in cells is explained in terms of the types and distribution of DNA DSBs, chromatin status, DNA terminal structures, DNA terminal excision, and cell cycles. This review is of great significance for the study of DNA damage repair and provides a reference for investigating the biological effects of heavy-ion radiation technology.http://www.fs.sinap.ac.cn/thesisDetails#10.11889/j.1000-3436.2022-0081&lang=zhheavy-ion beam radiationdna damageclustered dsbsdna damage repair |
| spellingShingle | REN Junle GUO Xiaopeng LEI Cairong ZHANG Miaomiao CHAI Ran LU Dong Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism Fushe yanjiu yu fushe gongyi xuebao heavy-ion beam radiation dna damage clustered dsbs dna damage repair |
| title | Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism |
| title_full | Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism |
| title_fullStr | Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism |
| title_full_unstemmed | Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism |
| title_short | Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism |
| title_sort | progress of research on double strand break damage induced by heavy ion beam radiation and repair mechanism |
| topic | heavy-ion beam radiation dna damage clustered dsbs dna damage repair |
| url | http://www.fs.sinap.ac.cn/thesisDetails#10.11889/j.1000-3436.2022-0081&lang=zh |
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