Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases
AIM: The current use of highly active antiretroviral therapy (HAART) for HIV/AIDS patients has increased the recognition of their hepatotoxic effects. The present study is aimed at evaluating the level of aspartate transaminase (AST) and alanine transaminase (ALT) in HIV patients on different classe...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2009-07-01
|
| Series: | Journal of Laboratory Physicians |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.59705 |
| _version_ | 1818064848903208960 |
|---|---|
| author | Ebele J Ikekpeazu Emeka E Neboh Ignatius C Maduka Odutola Odetunde Uche Ifejimalu |
| author_facet | Ebele J Ikekpeazu Emeka E Neboh Ignatius C Maduka Odutola Odetunde Uche Ifejimalu |
| author_sort | Ebele J Ikekpeazu |
| collection | DOAJ |
| description | AIM: The current use of highly active antiretroviral therapy (HAART) for HIV/AIDS patients has increased the recognition of their hepatotoxic effects. The present study is aimed at evaluating the level of aspartate transaminase (AST) and alanine transaminase (ALT) in HIV patients on different classes of HAART, for various durations, which causes its toxicity
Materials and Methods: The AST and ALT levels were estimated in a total of 340 subjects, of which 290 were HIV positive subjects drawn from patients attending the HIV clinic in two Teaching Hospitals, in Nigeria. 240 of the HIV patients were divided into 3 equal groups of 80 each and placed on non-nucleoside reverse transcriptase inhibitors (NNRTI), nucleoside reverse transcriptase inhibitors (NRTI), and protease inhibitors (PI), respectively, and were monitored for different periods of time (3, 6, 12, and >12 months). 50 of the HIV patients, yet to be placed on anti-retroviral therapy and 50 apparently healthy HIV-negative subjects served as the positive and negative controls, respectively.
Results: A significant increase in enzyme levels was noted at three and six months in the NNRTI group, and at only three months in the NRTI and PI groups, when compared with the controls. However, increased ALT was observed at six months in those on PI. The increased ALT and AST levels noted in the NNRTI group were significant when compared to those on NRTI and PI over a three- and six-month duration.
Conclusion: Liver enzyme activities were generally raised in the first three months of HAART, and further in the NNRTI group, after which they progressively fell to the normal level, with time. The highest degree was observed with NNRTIbased HAART. |
| first_indexed | 2024-12-10T14:42:31Z |
| format | Article |
| id | doaj.art-58ee83289f08425fbac953b31426ecc3 |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-12-10T14:42:31Z |
| publishDate | 2009-07-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-58ee83289f08425fbac953b31426ecc32022-12-22T01:44:40ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262009-07-0110207708110.4103/0974-2727.59705Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on TransaminasesEbele J Ikekpeazu0Emeka E Neboh1Ignatius C Maduka2Odutola Odetunde3Uche Ifejimalu4Department of Medical Biochemistry, College of Medicine, University of Nigeria Enugu Campus (UNEC), Enugu State, NigeriaDepartment of Chemical Pathology and Paediatrics, College of Medicine, Enugu State, University Teaching Hospital (ESUTH), Enugu State, NigeriaDepartment of Chemical Pathology, University of Nigeria Teaching Hospital (UNTH), PMB, 01129, Enugu, NigeriaDepartment of Paediatrics, College of Medicine, Enugu State, University Teaching Hospital (ESUTH), Enugu State, NigeriaDepartment of Medical Laboratory Sciences, Ambrose Alli University (AAU), Ekpoma, Edo State, NigeriaAIM: The current use of highly active antiretroviral therapy (HAART) for HIV/AIDS patients has increased the recognition of their hepatotoxic effects. The present study is aimed at evaluating the level of aspartate transaminase (AST) and alanine transaminase (ALT) in HIV patients on different classes of HAART, for various durations, which causes its toxicity Materials and Methods: The AST and ALT levels were estimated in a total of 340 subjects, of which 290 were HIV positive subjects drawn from patients attending the HIV clinic in two Teaching Hospitals, in Nigeria. 240 of the HIV patients were divided into 3 equal groups of 80 each and placed on non-nucleoside reverse transcriptase inhibitors (NNRTI), nucleoside reverse transcriptase inhibitors (NRTI), and protease inhibitors (PI), respectively, and were monitored for different periods of time (3, 6, 12, and >12 months). 50 of the HIV patients, yet to be placed on anti-retroviral therapy and 50 apparently healthy HIV-negative subjects served as the positive and negative controls, respectively. Results: A significant increase in enzyme levels was noted at three and six months in the NNRTI group, and at only three months in the NRTI and PI groups, when compared with the controls. However, increased ALT was observed at six months in those on PI. The increased ALT and AST levels noted in the NNRTI group were significant when compared to those on NRTI and PI over a three- and six-month duration. Conclusion: Liver enzyme activities were generally raised in the first three months of HAART, and further in the NNRTI group, after which they progressively fell to the normal level, with time. The highest degree was observed with NNRTIbased HAART.http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.59705durationeffectshiv-patientshighly active antiretroviral therapyliver enzymes |
| spellingShingle | Ebele J Ikekpeazu Emeka E Neboh Ignatius C Maduka Odutola Odetunde Uche Ifejimalu Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases Journal of Laboratory Physicians duration effects hiv-patients highly active antiretroviral therapy liver enzymes |
| title | Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases |
| title_full | Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases |
| title_fullStr | Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases |
| title_full_unstemmed | Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases |
| title_short | Long-Term Effect of Different Classes of Highly Active Antiretroviral Therapy on Transaminases |
| title_sort | long term effect of different classes of highly active antiretroviral therapy on transaminases |
| topic | duration effects hiv-patients highly active antiretroviral therapy liver enzymes |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/0974-2727.59705 |
| work_keys_str_mv | AT ebelejikekpeazu longtermeffectofdifferentclassesofhighlyactiveantiretroviraltherapyontransaminases AT emekaeneboh longtermeffectofdifferentclassesofhighlyactiveantiretroviraltherapyontransaminases AT ignatiuscmaduka longtermeffectofdifferentclassesofhighlyactiveantiretroviraltherapyontransaminases AT odutolaodetunde longtermeffectofdifferentclassesofhighlyactiveantiretroviraltherapyontransaminases AT ucheifejimalu longtermeffectofdifferentclassesofhighlyactiveantiretroviraltherapyontransaminases |