Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation
Overactive inflammatory responses contribute to progressive cardiac dysfunction after myocardial infarction (MI). Mesenchymal stem cell (MSC) has generated significant interest as potent immune modulators that can regulate excessive immune responses. We hypothesized that intravenous (iv) administrat...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2023-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2023/6256115 |
| _version_ | 1797860419350560768 |
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| author | Xiaoting Liang Jing Liu Mimi Li Fang Lin Rulin Zhuang Qingshu Meng Xiaoxue Ma Yuanfeng Xin Xin Gong Zhiying He Wei Han Xiaohui Zhou Zhongmin Liu |
| author_facet | Xiaoting Liang Jing Liu Mimi Li Fang Lin Rulin Zhuang Qingshu Meng Xiaoxue Ma Yuanfeng Xin Xin Gong Zhiying He Wei Han Xiaohui Zhou Zhongmin Liu |
| author_sort | Xiaoting Liang |
| collection | DOAJ |
| description | Overactive inflammatory responses contribute to progressive cardiac dysfunction after myocardial infarction (MI). Mesenchymal stem cell (MSC) has generated significant interest as potent immune modulators that can regulate excessive immune responses. We hypothesized that intravenous (iv) administration of human umbilical cord-derived MSC (HucMSC) exerts systemic and local anti-inflammation effects, leading to improved heart function after MI. In murine MI models, we confirmed that single iv administration of HucMSC (30×104) improved cardiac performance and prevented adverse remodeling after MI. A small proportion of HucMSC is trafficked to the heart, preferentially in the infarcted region. HucMSC administration increased CD3+ T cell proportion in the periphery while decreased T cell proportion in both infarcted heart and mediastinal lymph nodes (med-LN) at 7-day post-MI, indicating a systematic and local T cell interchange mediated by HucMSC. The inhibitory effects of HucMSC on T cell infiltration in the infarcted heart and med-LN sustained to 21-day post-MI. Our findings suggested that iv administration of HucMSC fostered systemic and local immunomodulatory effects that contributed to the improvement of cardiac performance after MI. |
| first_indexed | 2024-04-09T21:45:32Z |
| format | Article |
| id | doaj.art-58f0e61ce55546a69e03248cfe285563 |
| institution | Directory Open Access Journal |
| issn | 1687-9678 |
| language | English |
| last_indexed | 2024-04-09T21:45:32Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj.art-58f0e61ce55546a69e03248cfe2855632023-03-25T00:00:06ZengHindawi LimitedStem Cells International1687-96782023-01-01202310.1155/2023/6256115Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune ModulationXiaoting Liang0Jing Liu1Mimi Li2Fang Lin3Rulin Zhuang4Qingshu Meng5Xiaoxue Ma6Yuanfeng Xin7Xin Gong8Zhiying He9Wei Han10Xiaohui Zhou11Zhongmin Liu12Research Center for Translational MedicineResearch Center for Translational MedicineResearch Center for Translational MedicineResearch Center for Translational MedicineResearch Center for Translational MedicineResearch Center for Translational MedicineResearch Center for Translational MedicineResearch Center for Translational MedicineDepartment of Heart FailureInstitute for Regenerative MedicineDepartment of Heart FailureResearch Center for Translational MedicineResearch Center for Translational MedicineOveractive inflammatory responses contribute to progressive cardiac dysfunction after myocardial infarction (MI). Mesenchymal stem cell (MSC) has generated significant interest as potent immune modulators that can regulate excessive immune responses. We hypothesized that intravenous (iv) administration of human umbilical cord-derived MSC (HucMSC) exerts systemic and local anti-inflammation effects, leading to improved heart function after MI. In murine MI models, we confirmed that single iv administration of HucMSC (30×104) improved cardiac performance and prevented adverse remodeling after MI. A small proportion of HucMSC is trafficked to the heart, preferentially in the infarcted region. HucMSC administration increased CD3+ T cell proportion in the periphery while decreased T cell proportion in both infarcted heart and mediastinal lymph nodes (med-LN) at 7-day post-MI, indicating a systematic and local T cell interchange mediated by HucMSC. The inhibitory effects of HucMSC on T cell infiltration in the infarcted heart and med-LN sustained to 21-day post-MI. Our findings suggested that iv administration of HucMSC fostered systemic and local immunomodulatory effects that contributed to the improvement of cardiac performance after MI.http://dx.doi.org/10.1155/2023/6256115 |
| spellingShingle | Xiaoting Liang Jing Liu Mimi Li Fang Lin Rulin Zhuang Qingshu Meng Xiaoxue Ma Yuanfeng Xin Xin Gong Zhiying He Wei Han Xiaohui Zhou Zhongmin Liu Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation Stem Cells International |
| title | Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation |
| title_full | Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation |
| title_fullStr | Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation |
| title_full_unstemmed | Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation |
| title_short | Intravenously Administered Human Umbilical Cord-Derived Mesenchymal Stem Cell (HucMSC) Improves Cardiac Performance following Infarction via Immune Modulation |
| title_sort | intravenously administered human umbilical cord derived mesenchymal stem cell hucmsc improves cardiac performance following infarction via immune modulation |
| url | http://dx.doi.org/10.1155/2023/6256115 |
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