Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes
Background. Cardiac masses (CM) represent a heterogeneous clinical scenario, and sex-related differences of these patients remain to be established. Purpose: To evaluate sex-related disparities in CMs regarding clinical presentation and outcomes. Material and Methods. The study cohort included 321 c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/8/2958 |
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| author | Francesco Angeli Luca Bergamaschi Andrea Rinaldi Pasquale Paolisso Matteo Armillotta Andrea Stefanizzi Angelo Sansonetti Sara Amicone Andrea Impellizzeri Francesca Bodega Lisa Canton Nicole Suma Damiano Fedele Davide Bertolini Francesco Pio Tattilo Daniele Cavallo Ornella Di Iuorio Khrystyna Ryabenko Marcello Casuso Alvarez Nazzareno Galiè Alberto Foà Carmine Pizzi |
| author_facet | Francesco Angeli Luca Bergamaschi Andrea Rinaldi Pasquale Paolisso Matteo Armillotta Andrea Stefanizzi Angelo Sansonetti Sara Amicone Andrea Impellizzeri Francesca Bodega Lisa Canton Nicole Suma Damiano Fedele Davide Bertolini Francesco Pio Tattilo Daniele Cavallo Ornella Di Iuorio Khrystyna Ryabenko Marcello Casuso Alvarez Nazzareno Galiè Alberto Foà Carmine Pizzi |
| author_sort | Francesco Angeli |
| collection | DOAJ |
| description | Background. Cardiac masses (CM) represent a heterogeneous clinical scenario, and sex-related differences of these patients remain to be established. Purpose: To evaluate sex-related disparities in CMs regarding clinical presentation and outcomes. Material and Methods. The study cohort included 321 consecutive patients with CM enrolled in our Centre between 2004 and 2022. A definitive diagnosis was achieved by histological examination or, in the case of cardiac thrombi, with radiological evidence of thrombus resolution after anticoagulant treatment. All-cause mortality at follow-up was evaluated. Multivariable regression analysis assessed the potential prognostic disparities between men and women. Results. Out of 321 patients with CM, 172 (54%) were female. Women were more frequently younger (<i>p</i> = 0.02) than men. Regarding CM histotypes, females were affected by benign masses more frequently (with cardiac myxoma above all), while metastatic tumours were more common in men (<i>p</i> < 0.001). At presentation, peripheral embolism occurred predominantly in women (<i>p</i> = 0.03). Echocardiographic features such as greater dimension, irregular margin, infiltration, sessile mass and immobility were far more common in men. Despite a better overall survival in women, no sex-related differences were observed in the prognosis of benign or malignant masses. In fact, in multivariate analyses, sex was not independently associated with all-cause death. Conversely, age, smoking habit, malignant tumours and peripheral embolism were independent predictors of mortality. Conclusions. In a large cohort of cardiac masses, a significant sex-related difference in histotype prevalence was found: Benign CMs affected female patients more frequently, while malignant tumours affected predominantly men. Despite better overall survival in women, sex did not influence prognosis in benign and malignant masses. |
| first_indexed | 2024-03-11T04:52:53Z |
| format | Article |
| id | doaj.art-58f2d0cdb2124b9f9fb6150b85c1a72c |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T04:52:53Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-58f2d0cdb2124b9f9fb6150b85c1a72c2023-11-17T19:50:51ZengMDPI AGJournal of Clinical Medicine2077-03832023-04-01128295810.3390/jcm12082958Sex-Related Disparities in Cardiac Masses: Clinical Features and OutcomesFrancesco Angeli0Luca Bergamaschi1Andrea Rinaldi2Pasquale Paolisso3Matteo Armillotta4Andrea Stefanizzi5Angelo Sansonetti6Sara Amicone7Andrea Impellizzeri8Francesca Bodega9Lisa Canton10Nicole Suma11Damiano Fedele12Davide Bertolini13Francesco Pio Tattilo14Daniele Cavallo15Ornella Di Iuorio16Khrystyna Ryabenko17Marcello Casuso Alvarez18Nazzareno Galiè19Alberto Foà20Carmine Pizzi21Cardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyDepartment of Advanced Biomedical Sciences, University Federico II, 80131 Naples, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyCardiology Unit, IRCCS Azienda Ospedaliera-Universitaria di Bologna, 40138 Bologna, ItalyBackground. Cardiac masses (CM) represent a heterogeneous clinical scenario, and sex-related differences of these patients remain to be established. Purpose: To evaluate sex-related disparities in CMs regarding clinical presentation and outcomes. Material and Methods. The study cohort included 321 consecutive patients with CM enrolled in our Centre between 2004 and 2022. A definitive diagnosis was achieved by histological examination or, in the case of cardiac thrombi, with radiological evidence of thrombus resolution after anticoagulant treatment. All-cause mortality at follow-up was evaluated. Multivariable regression analysis assessed the potential prognostic disparities between men and women. Results. Out of 321 patients with CM, 172 (54%) were female. Women were more frequently younger (<i>p</i> = 0.02) than men. Regarding CM histotypes, females were affected by benign masses more frequently (with cardiac myxoma above all), while metastatic tumours were more common in men (<i>p</i> < 0.001). At presentation, peripheral embolism occurred predominantly in women (<i>p</i> = 0.03). Echocardiographic features such as greater dimension, irregular margin, infiltration, sessile mass and immobility were far more common in men. Despite a better overall survival in women, no sex-related differences were observed in the prognosis of benign or malignant masses. In fact, in multivariate analyses, sex was not independently associated with all-cause death. Conversely, age, smoking habit, malignant tumours and peripheral embolism were independent predictors of mortality. Conclusions. In a large cohort of cardiac masses, a significant sex-related difference in histotype prevalence was found: Benign CMs affected female patients more frequently, while malignant tumours affected predominantly men. Despite better overall survival in women, sex did not influence prognosis in benign and malignant masses.https://www.mdpi.com/2077-0383/12/8/2958cardio-oncologycardiac massesgender medicineechocardiography |
| spellingShingle | Francesco Angeli Luca Bergamaschi Andrea Rinaldi Pasquale Paolisso Matteo Armillotta Andrea Stefanizzi Angelo Sansonetti Sara Amicone Andrea Impellizzeri Francesca Bodega Lisa Canton Nicole Suma Damiano Fedele Davide Bertolini Francesco Pio Tattilo Daniele Cavallo Ornella Di Iuorio Khrystyna Ryabenko Marcello Casuso Alvarez Nazzareno Galiè Alberto Foà Carmine Pizzi Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes Journal of Clinical Medicine cardio-oncology cardiac masses gender medicine echocardiography |
| title | Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes |
| title_full | Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes |
| title_fullStr | Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes |
| title_full_unstemmed | Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes |
| title_short | Sex-Related Disparities in Cardiac Masses: Clinical Features and Outcomes |
| title_sort | sex related disparities in cardiac masses clinical features and outcomes |
| topic | cardio-oncology cardiac masses gender medicine echocardiography |
| url | https://www.mdpi.com/2077-0383/12/8/2958 |
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