Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer
Black phosphorus (BP) is one of the most promising nanomaterials for cancer therapy. This 2D material is biocompatible and has strong photocatalytic activity, making it a powerful photosensitiser for combined NIR photothermal and photodynamic therapies. However, the fast degradation of BP in oxic co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/1/115 |
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| author | Chandrima Das Cristina Martín Sebastian Habermann Harriet Rose Walker Javed Iqbal Jacobo Elies Huw Simon Jones Giacomo Reina Amalia Ruiz |
| author_facet | Chandrima Das Cristina Martín Sebastian Habermann Harriet Rose Walker Javed Iqbal Jacobo Elies Huw Simon Jones Giacomo Reina Amalia Ruiz |
| author_sort | Chandrima Das |
| collection | DOAJ |
| description | Black phosphorus (BP) is one of the most promising nanomaterials for cancer therapy. This 2D material is biocompatible and has strong photocatalytic activity, making it a powerful photosensitiser for combined NIR photothermal and photodynamic therapies. However, the fast degradation of BP in oxic conditions (including biological environments) still limits its use in cancer therapy. This work proposes a facile strategy to produce stable and highly concentrated BP suspensions using lysolipid temperature-sensitive liposomes (LTSLs). This approach also allows for co-encapsulating BP nanoflakes and doxorubicin, a potent chemotherapeutic drug. Finally, we demonstrate that our BP/doxorubicin formulation shows per se high antiproliferative action against an in vitro prostate cancer model and that the anticancer activity can be enhanced through NIR irradiance. |
| first_indexed | 2024-03-08T15:06:19Z |
| format | Article |
| id | doaj.art-58f4c53c584942a89bbae1260959c0ab |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T15:06:19Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-58f4c53c584942a89bbae1260959c0ab2024-01-10T14:58:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0125111510.3390/ijms25010115Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate CancerChandrima Das0Cristina Martín1Sebastian Habermann2Harriet Rose Walker3Javed Iqbal4Jacobo Elies5Huw Simon Jones6Giacomo Reina7Amalia Ruiz8Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKDepartment of Bioengineering, Universidad Carlos III de Madrid, 28911 Leganés, SpainEmpa Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, SwitzerlandInstitute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKInstitute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKInstitute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKInstitute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKEmpa Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, 9014 St. Gallen, SwitzerlandInstitute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UKBlack phosphorus (BP) is one of the most promising nanomaterials for cancer therapy. This 2D material is biocompatible and has strong photocatalytic activity, making it a powerful photosensitiser for combined NIR photothermal and photodynamic therapies. However, the fast degradation of BP in oxic conditions (including biological environments) still limits its use in cancer therapy. This work proposes a facile strategy to produce stable and highly concentrated BP suspensions using lysolipid temperature-sensitive liposomes (LTSLs). This approach also allows for co-encapsulating BP nanoflakes and doxorubicin, a potent chemotherapeutic drug. Finally, we demonstrate that our BP/doxorubicin formulation shows per se high antiproliferative action against an in vitro prostate cancer model and that the anticancer activity can be enhanced through NIR irradiance.https://www.mdpi.com/1422-0067/25/1/115black phosphorus nanoflakesphototherapyphotodynamic therapyLTSL |
| spellingShingle | Chandrima Das Cristina Martín Sebastian Habermann Harriet Rose Walker Javed Iqbal Jacobo Elies Huw Simon Jones Giacomo Reina Amalia Ruiz Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer International Journal of Molecular Sciences black phosphorus nanoflakes phototherapy photodynamic therapy LTSL |
| title | Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer |
| title_full | Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer |
| title_fullStr | Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer |
| title_full_unstemmed | Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer |
| title_short | Co-Loading of Black Phosphorus Nanoflakes and Doxorubicin in Lysolipid Temperature-Sensitive Liposomes for Combination Therapy in Prostate Cancer |
| title_sort | co loading of black phosphorus nanoflakes and doxorubicin in lysolipid temperature sensitive liposomes for combination therapy in prostate cancer |
| topic | black phosphorus nanoflakes phototherapy photodynamic therapy LTSL |
| url | https://www.mdpi.com/1422-0067/25/1/115 |
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