Developmental Origins and Nephron Endowment in Hypertension
Primary hypertension continues to be one of the main risk factors for cardiovascular disease worldwide. A stable intrauterine environment is critical for the future development and health of the fetus. The developing kidney has been found to be especially vulnerable during this time period, and epid...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-06-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fped.2017.00151/full |
| _version_ | 1819262162418270208 |
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| author | Shari Gurusinghe Anita Tambay Christine B. Sethna |
| author_facet | Shari Gurusinghe Anita Tambay Christine B. Sethna |
| author_sort | Shari Gurusinghe |
| collection | DOAJ |
| description | Primary hypertension continues to be one of the main risk factors for cardiovascular disease worldwide. A stable intrauterine environment is critical for the future development and health of the fetus. The developing kidney has been found to be especially vulnerable during this time period, and epidemiological studies have demonstrated that an adverse in utero environment is associated with an increased risk of hypertension and chronic kidney disease. Macro- and micronutrient deficiencies as well as exposure to tobacco, alcohol, and certain medications during gestation have been shown to negatively impact nephrogenesis and reduce one’s nephron number. In 1988, Brenner et al. put forth the controversial hypothesis that a reduced nephron complement is a risk factor for hypertension and chronic kidney disease in adulthood. Since then numerous animal and human studies have confirmed this relationship demonstrating that there is an inverse association between blood pressure and nephron number. As our understanding of the developmental programming of hypertension and other non-communicable diseases improves, more effective preventive health measures can be developed in the future. |
| first_indexed | 2024-12-23T19:53:19Z |
| format | Article |
| id | doaj.art-58f736955d644d4ab9606d3b1fcfba86 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-23T19:53:19Z |
| publishDate | 2017-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-58f736955d644d4ab9606d3b1fcfba862022-12-21T17:33:19ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602017-06-01510.3389/fped.2017.00151270280Developmental Origins and Nephron Endowment in HypertensionShari Gurusinghe0Anita Tambay1Christine B. Sethna2Department of Pediatrics, Division of Pediatric Nephrology, Cohen Children’s Medical Center of New York, New York, NY, United StatesDepartment of Pediatrics, Division of Pediatric Nephrology, Cohen Children’s Medical Center of New York, New York, NY, United StatesDepartment of Pediatrics, Division of Pediatric Nephrology, Cohen Children’s Medical Center of New York, New York, NY, United StatesPrimary hypertension continues to be one of the main risk factors for cardiovascular disease worldwide. A stable intrauterine environment is critical for the future development and health of the fetus. The developing kidney has been found to be especially vulnerable during this time period, and epidemiological studies have demonstrated that an adverse in utero environment is associated with an increased risk of hypertension and chronic kidney disease. Macro- and micronutrient deficiencies as well as exposure to tobacco, alcohol, and certain medications during gestation have been shown to negatively impact nephrogenesis and reduce one’s nephron number. In 1988, Brenner et al. put forth the controversial hypothesis that a reduced nephron complement is a risk factor for hypertension and chronic kidney disease in adulthood. Since then numerous animal and human studies have confirmed this relationship demonstrating that there is an inverse association between blood pressure and nephron number. As our understanding of the developmental programming of hypertension and other non-communicable diseases improves, more effective preventive health measures can be developed in the future.http://journal.frontiersin.org/article/10.3389/fped.2017.00151/fullhypertensionnephronfetal origins hypothesislow birth weightblood pressure |
| spellingShingle | Shari Gurusinghe Anita Tambay Christine B. Sethna Developmental Origins and Nephron Endowment in Hypertension Frontiers in Pediatrics hypertension nephron fetal origins hypothesis low birth weight blood pressure |
| title | Developmental Origins and Nephron Endowment in Hypertension |
| title_full | Developmental Origins and Nephron Endowment in Hypertension |
| title_fullStr | Developmental Origins and Nephron Endowment in Hypertension |
| title_full_unstemmed | Developmental Origins and Nephron Endowment in Hypertension |
| title_short | Developmental Origins and Nephron Endowment in Hypertension |
| title_sort | developmental origins and nephron endowment in hypertension |
| topic | hypertension nephron fetal origins hypothesis low birth weight blood pressure |
| url | http://journal.frontiersin.org/article/10.3389/fped.2017.00151/full |
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