Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers
<p>Abstract</p> <p>Background</p> <p>We have previously described an alternative invasion-independent pathway of cancer metastasis in a murine mammary tumor model. This pathway is initiated by intravasation of tumor nests enveloped by endothelial cells of sinusoidal vas...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2004-04-01
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| Series: | BMC Medicine |
| Online Access: | http://www.biomedcentral.com/1741-7015/2/9 |
| _version_ | 1818208814691778560 |
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| author | Yoshida Sayaka Hoshi Nobuo Hashimoto Takeaki Saito Atsuko Ogura Go Yamaguchi Tomiko Sugino Takashi Goodison Steve Suzuki Toshimitsu |
| author_facet | Yoshida Sayaka Hoshi Nobuo Hashimoto Takeaki Saito Atsuko Ogura Go Yamaguchi Tomiko Sugino Takashi Goodison Steve Suzuki Toshimitsu |
| author_sort | Yoshida Sayaka |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>We have previously described an alternative invasion-independent pathway of cancer metastasis in a murine mammary tumor model. This pathway is initiated by intravasation of tumor nests enveloped by endothelial cells of sinusoidal vasculature within the tumor. In this study, we examined whether evidence for the invasion-independent pathway of metastasis is present in human cancers.</p> <p>Methods</p> <p>Archival specimens of 10 common types of human cancers were examined for the presence of sinusoidal vasculature enveloping tumor nests and subsequently generated endothelial-covered tumor emboli in efferent veins.</p> <p>Results</p> <p>A percentage of tumor emboli in all cancers was found to be enveloped by endothelial cells, but these structures were particularly prevalent in renal cell carcinomas, hepatocellular carcinomas and follicular thyroid carcinomas. A common feature of the vasculature in these tumors was the presence of dilated sinusoid-like structures surrounding tumor nests. A high mean vascular area within tumors, an indication of sinusoidal vascular development, was significantly related to the presence of endothelial-covered tumor emboli.</p> <p>Conclusions</p> <p>These results suggest that an invasion-independent metastatic pathway is possible in a wide variety of human cancers. Further investigation of this phenomenon may present new therapeutic strategies for the amelioration of cancer metastasis.</p> |
| first_indexed | 2024-12-12T04:50:48Z |
| format | Article |
| id | doaj.art-58f8b04aa7b84912a7d3ed90b3268634 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-12T04:50:48Z |
| publishDate | 2004-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-58f8b04aa7b84912a7d3ed90b32686342022-12-22T00:37:29ZengBMCBMC Medicine1741-70152004-04-0121910.1186/1741-7015-2-9Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancersYoshida SayakaHoshi NobuoHashimoto TakeakiSaito AtsukoOgura GoYamaguchi TomikoSugino TakashiGoodison SteveSuzuki Toshimitsu<p>Abstract</p> <p>Background</p> <p>We have previously described an alternative invasion-independent pathway of cancer metastasis in a murine mammary tumor model. This pathway is initiated by intravasation of tumor nests enveloped by endothelial cells of sinusoidal vasculature within the tumor. In this study, we examined whether evidence for the invasion-independent pathway of metastasis is present in human cancers.</p> <p>Methods</p> <p>Archival specimens of 10 common types of human cancers were examined for the presence of sinusoidal vasculature enveloping tumor nests and subsequently generated endothelial-covered tumor emboli in efferent veins.</p> <p>Results</p> <p>A percentage of tumor emboli in all cancers was found to be enveloped by endothelial cells, but these structures were particularly prevalent in renal cell carcinomas, hepatocellular carcinomas and follicular thyroid carcinomas. A common feature of the vasculature in these tumors was the presence of dilated sinusoid-like structures surrounding tumor nests. A high mean vascular area within tumors, an indication of sinusoidal vascular development, was significantly related to the presence of endothelial-covered tumor emboli.</p> <p>Conclusions</p> <p>These results suggest that an invasion-independent metastatic pathway is possible in a wide variety of human cancers. Further investigation of this phenomenon may present new therapeutic strategies for the amelioration of cancer metastasis.</p>http://www.biomedcentral.com/1741-7015/2/9 |
| spellingShingle | Yoshida Sayaka Hoshi Nobuo Hashimoto Takeaki Saito Atsuko Ogura Go Yamaguchi Tomiko Sugino Takashi Goodison Steve Suzuki Toshimitsu Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers BMC Medicine |
| title | Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers |
| title_full | Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers |
| title_fullStr | Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers |
| title_full_unstemmed | Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers |
| title_short | Morphological evidence for an invasion-independent metastasis pathway exists in multiple human cancers |
| title_sort | morphological evidence for an invasion independent metastasis pathway exists in multiple human cancers |
| url | http://www.biomedcentral.com/1741-7015/2/9 |
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