Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences

How both telomere stability is regulated and dysfunctional telomeres processed in quiescent cells is poorly understood. Here, the authors provide evidence that eroded telomeres in quiescent fission yeast are rearranged by homologous recombination through duplications of subtelomeric sequences.

Bibliographic Details
Main Authors: Laetitia Maestroni, Julien Audry, Samah Matmati, Benoit Arcangioli, Vincent Géli, Stéphane Coulon
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01894-6
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author Laetitia Maestroni
Julien Audry
Samah Matmati
Benoit Arcangioli
Vincent Géli
Stéphane Coulon
author_facet Laetitia Maestroni
Julien Audry
Samah Matmati
Benoit Arcangioli
Vincent Géli
Stéphane Coulon
author_sort Laetitia Maestroni
collection DOAJ
description How both telomere stability is regulated and dysfunctional telomeres processed in quiescent cells is poorly understood. Here, the authors provide evidence that eroded telomeres in quiescent fission yeast are rearranged by homologous recombination through duplications of subtelomeric sequences.
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spelling doaj.art-58fa5679f2cb4f44a271462967d04eee2022-12-21T18:32:11ZengNature PortfolioNature Communications2041-17232017-11-018111410.1038/s41467-017-01894-6Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequencesLaetitia Maestroni0Julien Audry1Samah Matmati2Benoit Arcangioli3Vincent Géli4Stéphane Coulon5Marseille Cancer Research Center (CRCM), CNRS, INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, Equipe labélisée Ligue contre le cancerMarseille Cancer Research Center (CRCM), CNRS, INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, Equipe labélisée Ligue contre le cancerMarseille Cancer Research Center (CRCM), CNRS, INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, Equipe labélisée Ligue contre le cancerDynamics of the Genome, UMR 3225 Genomes & Genetics; Institut PasteurMarseille Cancer Research Center (CRCM), CNRS, INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, Equipe labélisée Ligue contre le cancerMarseille Cancer Research Center (CRCM), CNRS, INSERM, Aix Marseille Univ, Institut Paoli-Calmettes, Equipe labélisée Ligue contre le cancerHow both telomere stability is regulated and dysfunctional telomeres processed in quiescent cells is poorly understood. Here, the authors provide evidence that eroded telomeres in quiescent fission yeast are rearranged by homologous recombination through duplications of subtelomeric sequences.https://doi.org/10.1038/s41467-017-01894-6
spellingShingle Laetitia Maestroni
Julien Audry
Samah Matmati
Benoit Arcangioli
Vincent Géli
Stéphane Coulon
Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
Nature Communications
title Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
title_full Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
title_fullStr Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
title_full_unstemmed Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
title_short Eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
title_sort eroded telomeres are rearranged in quiescent fission yeast cells through duplications of subtelomeric sequences
url https://doi.org/10.1038/s41467-017-01894-6
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AT samahmatmati erodedtelomeresarerearrangedinquiescentfissionyeastcellsthroughduplicationsofsubtelomericsequences
AT benoitarcangioli erodedtelomeresarerearrangedinquiescentfissionyeastcellsthroughduplicationsofsubtelomericsequences
AT vincentgeli erodedtelomeresarerearrangedinquiescentfissionyeastcellsthroughduplicationsofsubtelomericsequences
AT stephanecoulon erodedtelomeresarerearrangedinquiescentfissionyeastcellsthroughduplicationsofsubtelomericsequences