Chemical Images on Fingerprints Revealed with Mass Spectrometry
Commercially available UV-adsorbent TiO<sub>2</sub> nanoparticles were used to assist laser/desorption ionization in the course of matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). Titanium nano-powders proved extremely stable and efficient for small mole...
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MDPI AG
2021-06-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/12/5624 |
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| author | Andrea Carrà Luigi Falciola Giuseppe Cappelletti Lavinia Morosi Enrico Davoli |
| author_facet | Andrea Carrà Luigi Falciola Giuseppe Cappelletti Lavinia Morosi Enrico Davoli |
| author_sort | Andrea Carrà |
| collection | DOAJ |
| description | Commercially available UV-adsorbent TiO<sub>2</sub> nanoparticles were used to assist laser/desorption ionization in the course of matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). Titanium nano-powders proved extremely stable and efficient for small molecule ionization, with negligible background noise in the low mass region (<i>m</i>/<i>z</i> < 500 Da). Validation steps were carried out, assessing detection limits and comparing the results to those of the established DESI/Orbitrap technique. The new analytical method was used to reveal the molecular distribution of endogenous (lipids) and exogenous (analgesics and antipyretics) compounds in latent finger marks (LFMs). The detection limits of endogenous fatty acids and small molecules such as caffeine were in the range of fmol/mm<sup>2</sup> on LFMs. The technique separated overlapping latent finger marks, exploiting the differences in lipid expression of human skin. Finally, the method was used to prove contact between skin and objects contaminated by different substances, such as credit cards and paper clips, with chemical images that maintain the shape of the objects on the LFM. |
| first_indexed | 2024-03-10T10:18:25Z |
| format | Article |
| id | doaj.art-58fa8f62a2fe4b7ea7f78101a7dc0b40 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T10:18:25Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
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| series | Applied Sciences |
| spelling | doaj.art-58fa8f62a2fe4b7ea7f78101a7dc0b402023-11-22T00:37:29ZengMDPI AGApplied Sciences2076-34172021-06-011112562410.3390/app11125624Chemical Images on Fingerprints Revealed with Mass SpectrometryAndrea Carrà0Luigi Falciola1Giuseppe Cappelletti2Lavinia Morosi3Enrico Davoli4Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, ItalyDipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, ItalyDipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milan, ItalyIstituto di Ricerche Farmacologiche Mario Negri IRCCS, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, ItalyDepartment of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, ItalyCommercially available UV-adsorbent TiO<sub>2</sub> nanoparticles were used to assist laser/desorption ionization in the course of matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI). Titanium nano-powders proved extremely stable and efficient for small molecule ionization, with negligible background noise in the low mass region (<i>m</i>/<i>z</i> < 500 Da). Validation steps were carried out, assessing detection limits and comparing the results to those of the established DESI/Orbitrap technique. The new analytical method was used to reveal the molecular distribution of endogenous (lipids) and exogenous (analgesics and antipyretics) compounds in latent finger marks (LFMs). The detection limits of endogenous fatty acids and small molecules such as caffeine were in the range of fmol/mm<sup>2</sup> on LFMs. The technique separated overlapping latent finger marks, exploiting the differences in lipid expression of human skin. Finally, the method was used to prove contact between skin and objects contaminated by different substances, such as credit cards and paper clips, with chemical images that maintain the shape of the objects on the LFM.https://www.mdpi.com/2076-3417/11/12/5624touch chemistrylatent finger marksmass spectrometry imagingdrugs |
| spellingShingle | Andrea Carrà Luigi Falciola Giuseppe Cappelletti Lavinia Morosi Enrico Davoli Chemical Images on Fingerprints Revealed with Mass Spectrometry Applied Sciences touch chemistry latent finger marks mass spectrometry imaging drugs |
| title | Chemical Images on Fingerprints Revealed with Mass Spectrometry |
| title_full | Chemical Images on Fingerprints Revealed with Mass Spectrometry |
| title_fullStr | Chemical Images on Fingerprints Revealed with Mass Spectrometry |
| title_full_unstemmed | Chemical Images on Fingerprints Revealed with Mass Spectrometry |
| title_short | Chemical Images on Fingerprints Revealed with Mass Spectrometry |
| title_sort | chemical images on fingerprints revealed with mass spectrometry |
| topic | touch chemistry latent finger marks mass spectrometry imaging drugs |
| url | https://www.mdpi.com/2076-3417/11/12/5624 |
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