Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>: Design, Synthesis, and Antiproliferative Activity

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAF<sup>V600E</sup>: Design, Synthesis, and Antiproliferative Activity

A novel series of hybrid compounds comprising quinazolin-4-one and 3-cyanopyridin-2-one structures has been developed, with dual inhibitory actions on both EGFR and BRAF<sup>V600E</sup>. These hybrid compounds were tested in vitro against four different cancer cell lines. Compounds <b...

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Bibliographic Details
Main Authors: Lamya H. Al-Wahaibi, Mohamed Hisham, Hesham A. Abou-Zied, Heba A. Hassan, Bahaa G. M. Youssif, Stefan Bräse, Alaa M. Hayallah, Mohamed Abdel-Aziz
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceuticals
Subjects:
quinazolin-4-one
3-cyanopyridin-2-one
EGFR
BRAF<sup>V600E</sup>
anti-cancer
docking
Online Access:https://www.mdpi.com/1424-8247/16/11/1522

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