Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds
Average daily gain (ADG) is an important growth trait in the pig industry. The direct genetic effect (DGE) has been studied mainly to assess the association between genetic information and economic traits. The social genetic effect (SGE) has been shown to affect ADG simultaneously with the DGE becau...
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MDPI AG
2022-09-01
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| Series: | Animals |
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| author | Ha-Seung Seong Young-Sin Kim Soo-Jin Sa Yongdae Jeong Joon-Ki Hong Eun-Seok Cho |
| author_facet | Ha-Seung Seong Young-Sin Kim Soo-Jin Sa Yongdae Jeong Joon-Ki Hong Eun-Seok Cho |
| author_sort | Ha-Seung Seong |
| collection | DOAJ |
| description | Average daily gain (ADG) is an important growth trait in the pig industry. The direct genetic effect (DGE) has been studied mainly to assess the association between genetic information and economic traits. The social genetic effect (SGE) has been shown to affect ADG simultaneously with the DGE because of group housing systems. We conducted this study to elucidate the genetic characteristics and relationships of the DGE and SGE of purebred Korean Duroc and crossbred pigs by single-step genomic best linear unbiased prediction and a genome-wide association study. We used the genotype, phenotype, and pedigree data of 1779, 6022, and 7904 animals, respectively. Total heritabilities on ADG were 0.19 ± 0.04 and 0.39 ± 0.08 for purebred and crossbred pigs, respectively. The genetic correlation was the greatest (0.77 ± 0.12) between the SGE of purebred and DGE of crossbred pigs. We found candidate genes located in the quantitative trait loci (QTLs) for the SGE that were associated with behavior and neurodegenerative diseases, and candidate genes in the QTLs for DGE that were related to body mass, size of muscle fiber, and muscle hypertrophy. These results suggest that the genomic selection of purebred animals could be applied for crossbred performance. |
| first_indexed | 2024-03-10T03:06:31Z |
| format | Article |
| id | doaj.art-58fc233de0ed449499370803fe8aca6b |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T03:06:31Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-58fc233de0ed449499370803fe8aca6b2023-11-23T12:38:40ZengMDPI AGAnimals2076-26152022-09-011217230010.3390/ani12172300Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and CrossbredsHa-Seung Seong0Young-Sin Kim1Soo-Jin Sa2Yongdae Jeong3Joon-Ki Hong4Eun-Seok Cho5National Institute of Animal Science, Rural Development Administration, Cheonan 31000, KoreaNational Institute of Animal Science, Rural Development Administration, Cheonan 31000, KoreaNational Institute of Animal Science, Rural Development Administration, Cheonan 31000, KoreaNational Institute of Animal Science, Rural Development Administration, Cheonan 31000, KoreaNational Institute of Animal Science, Rural Development Administration, Cheonan 31000, KoreaNational Institute of Animal Science, Rural Development Administration, Cheonan 31000, KoreaAverage daily gain (ADG) is an important growth trait in the pig industry. The direct genetic effect (DGE) has been studied mainly to assess the association between genetic information and economic traits. The social genetic effect (SGE) has been shown to affect ADG simultaneously with the DGE because of group housing systems. We conducted this study to elucidate the genetic characteristics and relationships of the DGE and SGE of purebred Korean Duroc and crossbred pigs by single-step genomic best linear unbiased prediction and a genome-wide association study. We used the genotype, phenotype, and pedigree data of 1779, 6022, and 7904 animals, respectively. Total heritabilities on ADG were 0.19 ± 0.04 and 0.39 ± 0.08 for purebred and crossbred pigs, respectively. The genetic correlation was the greatest (0.77 ± 0.12) between the SGE of purebred and DGE of crossbred pigs. We found candidate genes located in the quantitative trait loci (QTLs) for the SGE that were associated with behavior and neurodegenerative diseases, and candidate genes in the QTLs for DGE that were related to body mass, size of muscle fiber, and muscle hypertrophy. These results suggest that the genomic selection of purebred animals could be applied for crossbred performance.https://www.mdpi.com/2076-2615/12/17/2300social genetic effectaverage daily gainpurebredcrossbred |
| spellingShingle | Ha-Seung Seong Young-Sin Kim Soo-Jin Sa Yongdae Jeong Joon-Ki Hong Eun-Seok Cho Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds Animals social genetic effect average daily gain purebred crossbred |
| title | Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds |
| title_full | Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds |
| title_fullStr | Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds |
| title_full_unstemmed | Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds |
| title_short | Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds |
| title_sort | genetic parameter estimation and genome wide association analysis of social genetic effects on average daily gain in purebreds and crossbreds |
| topic | social genetic effect average daily gain purebred crossbred |
| url | https://www.mdpi.com/2076-2615/12/17/2300 |
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