Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65
Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathotype in addition to classical Klebsiella pneumoniae, with its ability to cause life-threatening, community-acquired metastatic infections even in healthy individuals. We presented a case of cerebral abscess preceded by otitis media in a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034123001703 |
| _version_ | 1797814404557832192 |
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| author | Emily Tan Sheau En Nabilah Ismail Nur Syafiqah Mohamad Nasir Yasmin Khairani Muhammad Ismadi Nik Mohd Noor Nik Zuraina Siti Asma’ Hassan |
| author_facet | Emily Tan Sheau En Nabilah Ismail Nur Syafiqah Mohamad Nasir Yasmin Khairani Muhammad Ismadi Nik Mohd Noor Nik Zuraina Siti Asma’ Hassan |
| author_sort | Emily Tan Sheau En |
| collection | DOAJ |
| description | Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathotype in addition to classical Klebsiella pneumoniae, with its ability to cause life-threatening, community-acquired metastatic infections even in healthy individuals. We presented a case of cerebral abscess preceded by otitis media in a 10-year-old child caused by hvKp. The isolates from blood pus aspirate were later identified as K. pneumoniae capsular serotype K2 and closely related to sequence type (ST65), with multiple hypervirulent genes detected (rmpA, rmpA2, iucA and peg344). She succumbed to death despite surgical drainage and susceptible antibiotic therapy. Clinicians should be cognizant of the rising incidence of hvKp infections in pediatric populations. |
| first_indexed | 2024-03-13T08:07:17Z |
| format | Article |
| id | doaj.art-58fe724caf9242f3b2f33c2c4043adbb |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-03-13T08:07:17Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-58fe724caf9242f3b2f33c2c4043adbb2023-06-01T04:35:27ZengElsevierJournal of Infection and Public Health1876-03412023-07-0116710891092Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65Emily Tan Sheau En0Nabilah Ismail1Nur Syafiqah Mohamad Nasir2Yasmin Khairani Muhammad Ismadi3Nik Mohd Noor Nik Zuraina4Siti Asma’ Hassan5Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, Health Campus, USM, 16150 Kubang Kerian, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, MalaysiaDepartment of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia; Hospital Universiti Sains Malaysia, Health Campus, USM, 16150 Kubang Kerian, Malaysia; Corresponding author at: Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathotype in addition to classical Klebsiella pneumoniae, with its ability to cause life-threatening, community-acquired metastatic infections even in healthy individuals. We presented a case of cerebral abscess preceded by otitis media in a 10-year-old child caused by hvKp. The isolates from blood pus aspirate were later identified as K. pneumoniae capsular serotype K2 and closely related to sequence type (ST65), with multiple hypervirulent genes detected (rmpA, rmpA2, iucA and peg344). She succumbed to death despite surgical drainage and susceptible antibiotic therapy. Clinicians should be cognizant of the rising incidence of hvKp infections in pediatric populations.http://www.sciencedirect.com/science/article/pii/S1876034123001703HypervirulentKlebsiella pneumoniaePediatricBrain abscess |
| spellingShingle | Emily Tan Sheau En Nabilah Ismail Nur Syafiqah Mohamad Nasir Yasmin Khairani Muhammad Ismadi Nik Mohd Noor Nik Zuraina Siti Asma’ Hassan Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65 Journal of Infection and Public Health Hypervirulent Klebsiella pneumoniae Pediatric Brain abscess |
| title | Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65 |
| title_full | Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65 |
| title_fullStr | Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65 |
| title_full_unstemmed | Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65 |
| title_short | Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65 |
| title_sort | pediatric brain abscess with fatal outcome caused by hypervirulent klebsiella pneumoniae serotype k2 st65 |
| topic | Hypervirulent Klebsiella pneumoniae Pediatric Brain abscess |
| url | http://www.sciencedirect.com/science/article/pii/S1876034123001703 |
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