Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment
Abstract Background Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagn...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2023-08-01
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| Series: | Biomaterials Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40824-023-00418-2 |
| _version_ | 1827331711345623040 |
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| author | Eun Sook Lee Hyewon Ko Chan Ho Kim Hyun-Chul Kim Seong-Kyoon Choi Sang Won Jeong Se-Guen Lee Sung-Jun Lee Hee-Kyung Na Jae Hyung Park Jung Min Shin |
| author_facet | Eun Sook Lee Hyewon Ko Chan Ho Kim Hyun-Chul Kim Seong-Kyoon Choi Sang Won Jeong Se-Guen Lee Sung-Jun Lee Hee-Kyung Na Jae Hyung Park Jung Min Shin |
| author_sort | Eun Sook Lee |
| collection | DOAJ |
| description | Abstract Background Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy. Main body Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges. Conclusion This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment. Graphical Abstract |
| first_indexed | 2024-03-07T16:44:14Z |
| format | Article |
| id | doaj.art-58fffaf930bc49e9bf1e6fbe20b9c39b |
| institution | Directory Open Access Journal |
| issn | 2055-7124 |
| language | English |
| last_indexed | 2024-03-07T16:44:14Z |
| publishDate | 2023-08-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Biomaterials Research |
| spelling | doaj.art-58fffaf930bc49e9bf1e6fbe20b9c39b2024-03-03T06:55:04ZengAmerican Association for the Advancement of Science (AAAS)Biomaterials Research2055-71242023-08-0127113610.1186/s40824-023-00418-2Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatmentEun Sook Lee0Hyewon Ko1Chan Ho Kim2Hyun-Chul Kim3Seong-Kyoon Choi4Sang Won Jeong5Se-Guen Lee6Sung-Jun Lee7Hee-Kyung Na8Jae Hyung Park9Jung Min Shin10Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS)Bionanotechnology Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB)School of Chemical Engineering, Sungkyunkwan UniversityDivision of Biotechnology, Convergence Research Institute, DGISTDivision of Biotechnology, Convergence Research Institute, DGISTDivision of Biotechnology, Convergence Research Institute, DGISTDivision of Biotechnology, Convergence Research Institute, DGISTDivision of Biotechnology, Convergence Research Institute, DGISTSafety Measurement Institute, Korea Research Institute of Standards and Science (KRISS)School of Chemical Engineering, Sungkyunkwan UniversityDivision of Biotechnology, Convergence Research Institute, DGISTAbstract Background Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their application in various research areas, particularly in diagnostics and therapy. Main body Exosomes have great potential as biomarkers and delivery vehicles for encapsulating therapeutic cargo. However, the limitations of bare exosomes, such as rapid phagocytic clearance and non-specific biodistribution after injection, pose significant challenges to their application as drug delivery systems. This review focuses on exosome-based drug delivery for treating rheumatoid arthritis, emphasizing pre/post-engineering approaches to overcome these challenges. Conclusion This review will serve as an essential resource for future studies to develop novel exosome-based therapeutic approaches for rheumatoid arthritis. Overall, the review highlights the potential of exosomes as a promising therapeutic approach for rheumatoid arthritis treatment. Graphical Abstracthttps://doi.org/10.1186/s40824-023-00418-2ExosomeRheumatoid arthritisDisease microenvironmentEngineered exosome |
| spellingShingle | Eun Sook Lee Hyewon Ko Chan Ho Kim Hyun-Chul Kim Seong-Kyoon Choi Sang Won Jeong Se-Guen Lee Sung-Jun Lee Hee-Kyung Na Jae Hyung Park Jung Min Shin Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment Biomaterials Research Exosome Rheumatoid arthritis Disease microenvironment Engineered exosome |
| title | Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment |
| title_full | Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment |
| title_fullStr | Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment |
| title_full_unstemmed | Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment |
| title_short | Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment |
| title_sort | disease microenvironment modulation by bare or engineered exosome for rheumatoid arthritis treatment |
| topic | Exosome Rheumatoid arthritis Disease microenvironment Engineered exosome |
| url | https://doi.org/10.1186/s40824-023-00418-2 |
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