A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and my...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/5/969 |
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| author | Thaise Yasmine Vasconcelos de Lima Cavalcanti Mylena Ribeiro Pereira Sergio Oliveira de Paula Rafael Freitas de Oliveira Franca |
| author_facet | Thaise Yasmine Vasconcelos de Lima Cavalcanti Mylena Ribeiro Pereira Sergio Oliveira de Paula Rafael Freitas de Oliveira Franca |
| author_sort | Thaise Yasmine Vasconcelos de Lima Cavalcanti |
| collection | DOAJ |
| description | Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and myalgia that can last for weeks or months; however, severe disease presentation can also occur in a minor proportion of infections. Among the atypical CHIKV manifestations that have been described, severe arthralgia and neurological complications, such as encephalitis, meningitis, and Guillain–Barré Syndrome, are now reported in many outbreaks. Moreover, death cases were also reported, placing CHIKV as a relevant public health disease. Virus evolution, globalization, and climate change may have contributed to CHIKV spread. In addition to this, the lack of preventive vaccines and approved antiviral treatments is turning CHIKV into a major global health threat. In this review, we discuss the current knowledge about CHIKV pathogenesis, with a focus on atypical disease manifestations, such as persistent arthralgia and neurologic disease presentation. We also bring an up-to-date review of the current CHIKV vaccine development. Altogether, these topics highlight some of the most recent advances in our understanding of CHIKV pathogenesis and also provide important insights into the current development and clinical trials of CHIKV potential vaccine candidates. |
| first_indexed | 2024-03-10T01:37:25Z |
| format | Article |
| id | doaj.art-5900313c0440441c8b00f4f53c8a531e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T01:37:25Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-5900313c0440441c8b00f4f53c8a531e2023-11-23T13:31:04ZengMDPI AGViruses1999-49152022-05-0114596910.3390/v14050969A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine DevelopmentThaise Yasmine Vasconcelos de Lima Cavalcanti0Mylena Ribeiro Pereira1Sergio Oliveira de Paula2Rafael Freitas de Oliveira Franca3Department of Virology and Experimental Therapy, Fundação Oswaldo Cruz/Fiocruz, Recife 50740-465, PE, BrazilUniversidade Federal Rural de Pernambuco, Recife 52171-900, PE, BrazilDepartment of Biology, Universidade Federal de Viçosa, Viçosa 36570-900, MG, BrazilDepartment of Virology and Experimental Therapy, Fundação Oswaldo Cruz/Fiocruz, Recife 50740-465, PE, BrazilChikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile illness known as chikungunya fever (CHIKF). Infection is self-limited and characterized mainly by severe joint pain and myalgia that can last for weeks or months; however, severe disease presentation can also occur in a minor proportion of infections. Among the atypical CHIKV manifestations that have been described, severe arthralgia and neurological complications, such as encephalitis, meningitis, and Guillain–Barré Syndrome, are now reported in many outbreaks. Moreover, death cases were also reported, placing CHIKV as a relevant public health disease. Virus evolution, globalization, and climate change may have contributed to CHIKV spread. In addition to this, the lack of preventive vaccines and approved antiviral treatments is turning CHIKV into a major global health threat. In this review, we discuss the current knowledge about CHIKV pathogenesis, with a focus on atypical disease manifestations, such as persistent arthralgia and neurologic disease presentation. We also bring an up-to-date review of the current CHIKV vaccine development. Altogether, these topics highlight some of the most recent advances in our understanding of CHIKV pathogenesis and also provide important insights into the current development and clinical trials of CHIKV potential vaccine candidates.https://www.mdpi.com/1999-4915/14/5/969chikungunyapathogenesisvirus receptorvaccineimmunopathogenesisepidemiology |
| spellingShingle | Thaise Yasmine Vasconcelos de Lima Cavalcanti Mylena Ribeiro Pereira Sergio Oliveira de Paula Rafael Freitas de Oliveira Franca A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development Viruses chikungunya pathogenesis virus receptor vaccine immunopathogenesis epidemiology |
| title | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
| title_full | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
| title_fullStr | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
| title_full_unstemmed | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
| title_short | A Review on Chikungunya Virus Epidemiology, Pathogenesis and Current Vaccine Development |
| title_sort | review on chikungunya virus epidemiology pathogenesis and current vaccine development |
| topic | chikungunya pathogenesis virus receptor vaccine immunopathogenesis epidemiology |
| url | https://www.mdpi.com/1999-4915/14/5/969 |
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