Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols

Physiological Levels of Nitric Oxide Diminish Mitochondrial Superoxide. Potential Role of Mitochondrial Dinitrosyl Iron Complexes and Nitrosothiols

Mitochondria are the major source of superoxide radicals and superoxide overproduction contributes to cardiovascular diseases and metabolic disorders. Endothelial dysfunction and diminished nitric oxide levels are early steps in the development of these pathological conditions. It is known that phys...

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Bibliographic Details
Main Authors: Sergey I. Dikalov, Vladimir I. Mayorov, Alexander V. Panov
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Physiology
Subjects:
mitochondria
superoxide
nitric oxide
dinitrosyl iron complexes
nitrosothiols
electron spin resonance
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2017.00907/full

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