Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody–Drug Conjugates

Evaluation of Two Chemoenzymatic Glycan Remodeling Approaches to Generate Site-Specific Antibody–Drug Conjugates

Fc-glycosite-specific antibody–drug conjugation represents a promising direction for the preparation of site-specific antibody–drug conjugates (ADCs). In the present research, we conducted a systemic evaluation of two endoglycosidase-catalyzed chemoenzymatic glycoengineering technologies to prepare...

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Bibliographic Details
Main Authors: Qiang Yang, He Chen, Chong Ou, Zhihao Zheng, Xiao Zhang, Yunpeng Liu, Guanghui Zong, Lai-Xi Wang
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Antibodies
Subjects:
endoglycosidase
glycan oxazoline
chemoenzymatic glycan-remodeling
antibody-drug conjugates
Online Access:https://www.mdpi.com/2073-4468/12/4/71

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