Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials
Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host reti...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-01-01
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| Series: | Journal of Tissue Engineering |
| Online Access: | https://doi.org/10.1177/2041731417751286 |
| _version_ | 1819230104688001024 |
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| author | Ankush Thakur Shawn Mishra Juan Pena Jing Zhou Stephen Redenti Robert Majeska Maribel Vazquez |
| author_facet | Ankush Thakur Shawn Mishra Juan Pena Jing Zhou Stephen Redenti Robert Majeska Maribel Vazquez |
| author_sort | Ankush Thakur |
| collection | DOAJ |
| description | Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host retina. In this work, we examine the adhesion and displacement responses of retinal progenitor cells on extracellular matrix substrates found in retina as well as widely used in the design and preparation of transplantable scaffolds. The data illustrate that retinal progenitor cells exhibit unique adhesive and displacement dynamics in response to poly- l -lysine, fibronectin, laminin, hyaluronic acid, and Matrigel. These findings suggest that transplantable biomaterials can be designed to improve cell integration by incorporating extracellular matrix substrates that affect the migratory behaviors of replacement cells. |
| first_indexed | 2024-12-23T11:23:46Z |
| format | Article |
| id | doaj.art-59024e1d930a425b99934ad133949ae8 |
| institution | Directory Open Access Journal |
| issn | 2041-7314 |
| language | English |
| last_indexed | 2024-12-23T11:23:46Z |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Tissue Engineering |
| spelling | doaj.art-59024e1d930a425b99934ad133949ae82022-12-21T17:49:00ZengSAGE PublishingJournal of Tissue Engineering2041-73142018-01-01910.1177/2041731417751286Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterialsAnkush Thakur0Shawn Mishra1Juan Pena2Jing Zhou3Stephen Redenti4Robert Majeska5Maribel Vazquez6Department of Biomedical Engineering, The City College of New York, New York, NY, USADepartment of Biomedical Engineering, The City College of New York, New York, NY, USADepartment of Biomedical Engineering, The City College of New York, New York, NY, USABiology, The Graduate Center, The City University of New York, New York, NY, USABiochemistry, The Graduate Center, The City University of New York, New York, NY, USADepartment of Biomedical Engineering, The City College of New York, New York, NY, USABiochemistry, The Graduate Center, The City University of New York, New York, NY, USAStrategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host retina. In this work, we examine the adhesion and displacement responses of retinal progenitor cells on extracellular matrix substrates found in retina as well as widely used in the design and preparation of transplantable scaffolds. The data illustrate that retinal progenitor cells exhibit unique adhesive and displacement dynamics in response to poly- l -lysine, fibronectin, laminin, hyaluronic acid, and Matrigel. These findings suggest that transplantable biomaterials can be designed to improve cell integration by incorporating extracellular matrix substrates that affect the migratory behaviors of replacement cells.https://doi.org/10.1177/2041731417751286 |
| spellingShingle | Ankush Thakur Shawn Mishra Juan Pena Jing Zhou Stephen Redenti Robert Majeska Maribel Vazquez Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials Journal of Tissue Engineering |
| title | Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials |
| title_full | Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials |
| title_fullStr | Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials |
| title_full_unstemmed | Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials |
| title_short | Collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials |
| title_sort | collective adhesion and displacement of retinal progenitor cells upon extracellular matrix substrates of transplantable biomaterials |
| url | https://doi.org/10.1177/2041731417751286 |
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