Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved]
Basophils are mainly known as pro-inflammatory effector cells associated with allergy and helminth infections. Although they were identified over 130 years ago, their in vivo functions are still poorly understood. New insights into basophil development and function have been gained by the developmen...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-08-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/6-1464/v1 |
| _version_ | 1818466389822799872 |
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| author | David Voehringer |
| author_facet | David Voehringer |
| author_sort | David Voehringer |
| collection | DOAJ |
| description | Basophils are mainly known as pro-inflammatory effector cells associated with allergy and helminth infections. Although they were identified over 130 years ago, their in vivo functions are still poorly understood. New insights into basophil development and function have been gained by the development of various transgenic mouse lines and staining techniques to detect and purify these cells from different organs. Several studies over the past few years have identified unexpected functions for basophils, including immunomodulatory properties and interactions with other immune cells. Here, I summarize and discuss the main findings. |
| first_indexed | 2024-04-13T20:58:03Z |
| format | Article |
| id | doaj.art-5903bd2ea3494486b9985d6c65e443d7 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T20:58:03Z |
| publishDate | 2017-08-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-5903bd2ea3494486b9985d6c65e443d72022-12-22T02:30:15ZengF1000 Research LtdF1000Research2046-14022017-08-01610.12688/f1000research.11697.112638Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved]David Voehringer0Department of Infection Biology, University Hospital Erlangen, Erlangen, GermanyBasophils are mainly known as pro-inflammatory effector cells associated with allergy and helminth infections. Although they were identified over 130 years ago, their in vivo functions are still poorly understood. New insights into basophil development and function have been gained by the development of various transgenic mouse lines and staining techniques to detect and purify these cells from different organs. Several studies over the past few years have identified unexpected functions for basophils, including immunomodulatory properties and interactions with other immune cells. Here, I summarize and discuss the main findings.https://f1000research.com/articles/6-1464/v1Allergy & HypersensitivityAntigen Processing & RecognitionAutoimmunityClinical ImmunologyImmune & Inflammatory Rheumatic Diseases (incl. Arthritis)ImmunomodulationInnate ImmunityLeukocyte DevelopmentLeukocyte Signaling & Gene Expression |
| spellingShingle | David Voehringer Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved] F1000Research Allergy & Hypersensitivity Antigen Processing & Recognition Autoimmunity Clinical Immunology Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Immunomodulation Innate Immunity Leukocyte Development Leukocyte Signaling & Gene Expression |
| title | Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved] |
| title_full | Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved] |
| title_fullStr | Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved] |
| title_full_unstemmed | Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved] |
| title_short | Recent advances in understanding basophil functions in vivo [version 1; referees: 5 approved] |
| title_sort | recent advances in understanding basophil functions in vivo version 1 referees 5 approved |
| topic | Allergy & Hypersensitivity Antigen Processing & Recognition Autoimmunity Clinical Immunology Immune & Inflammatory Rheumatic Diseases (incl. Arthritis) Immunomodulation Innate Immunity Leukocyte Development Leukocyte Signaling & Gene Expression |
| url | https://f1000research.com/articles/6-1464/v1 |
| work_keys_str_mv | AT davidvoehringer recentadvancesinunderstandingbasophilfunctionsinvivoversion1referees5approved |