Peptic Ulcer Disease Associated with Central Obesity
This retrospective cross-sectional study aimed to evaluate associations between peptic ulcer disease (PUD), bone mineral density, and metabolic syndrome (MetS) and its components in healthy populations. Data were collected from the health examination database of a tertiary medical center in southern...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/12/1968 |
| _version_ | 1797456855168974848 |
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| author | Song-Seng Loke Wen-Cheng Li |
| author_facet | Song-Seng Loke Wen-Cheng Li |
| author_sort | Song-Seng Loke |
| collection | DOAJ |
| description | This retrospective cross-sectional study aimed to evaluate associations between peptic ulcer disease (PUD), bone mineral density, and metabolic syndrome (MetS) and its components in healthy populations. Data were collected from the health examination database of a tertiary medical center in southern Taiwan from January 2015 to December 2016. Subjects who had undergone metabolic factors assessment, upper gastrointestinal endoscopy, and dual energy X-ray absorptiometry scans were enrolled. In total, 5102 subjects were included, with mean age 52.4 ± 12.0 years. Among them, 1332 (26.1%) had PUD. Multivariate logistic regression analysis showed that age (OR 1.03, <i>p</i> < 0.001), male (OR 1.89, <i>p</i> < 0.001), diabetes (OR 1.23, <i>p</i> = 0.004), BMI (OR 1.03, <i>p</i> = 0.001), and GOT (OR 1, <i>p</i> = 0.003) are risk factors for PUD. Regarding MetS parameters, larger waist circumference (OR 1.26, <i>p</i> = 0.001) is associated with PUD, and high triglycerides (OR 1.20, 95% CI 1.01–1.43) is associated with gastric ulcer, while low HDL (OR 1.31, 95% CI 1.07–1.59) and osteoporosis (OR 1.44, 95% CI 1.08–1.91) are associated with duodenal ulcer. In conclusion, central obesity is associated with PUD in a middle-aged healthy population. Subjects with high triglycerides are prone to gastric ulcers, and those with osteoporosis and low HDL are prone to duodenal ulcers. |
| first_indexed | 2024-03-09T16:12:50Z |
| format | Article |
| id | doaj.art-5903e2f7bde942faa0c4935c1c2d9b50 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T16:12:50Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-5903e2f7bde942faa0c4935c1c2d9b502023-11-24T16:01:21ZengMDPI AGJournal of Personalized Medicine2075-44262022-11-011212196810.3390/jpm12121968Peptic Ulcer Disease Associated with Central ObesitySong-Seng Loke0Wen-Cheng Li1Division of Geriatric Medicine, Department of Family Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123, Dapi Road, Niaosong District, Kaohsiung 80708, TaiwanDepartment of Family Medicine, Chang Gung Memorial Hospital, Linkou Branch, College of Medicine, Chang-Gung University, Taoyuan 32023, TaiwanThis retrospective cross-sectional study aimed to evaluate associations between peptic ulcer disease (PUD), bone mineral density, and metabolic syndrome (MetS) and its components in healthy populations. Data were collected from the health examination database of a tertiary medical center in southern Taiwan from January 2015 to December 2016. Subjects who had undergone metabolic factors assessment, upper gastrointestinal endoscopy, and dual energy X-ray absorptiometry scans were enrolled. In total, 5102 subjects were included, with mean age 52.4 ± 12.0 years. Among them, 1332 (26.1%) had PUD. Multivariate logistic regression analysis showed that age (OR 1.03, <i>p</i> < 0.001), male (OR 1.89, <i>p</i> < 0.001), diabetes (OR 1.23, <i>p</i> = 0.004), BMI (OR 1.03, <i>p</i> = 0.001), and GOT (OR 1, <i>p</i> = 0.003) are risk factors for PUD. Regarding MetS parameters, larger waist circumference (OR 1.26, <i>p</i> = 0.001) is associated with PUD, and high triglycerides (OR 1.20, 95% CI 1.01–1.43) is associated with gastric ulcer, while low HDL (OR 1.31, 95% CI 1.07–1.59) and osteoporosis (OR 1.44, 95% CI 1.08–1.91) are associated with duodenal ulcer. In conclusion, central obesity is associated with PUD in a middle-aged healthy population. Subjects with high triglycerides are prone to gastric ulcers, and those with osteoporosis and low HDL are prone to duodenal ulcers.https://www.mdpi.com/2075-4426/12/12/1968peptic ulcer diseasemetabolic syndromecentral obesityhealth examination |
| spellingShingle | Song-Seng Loke Wen-Cheng Li Peptic Ulcer Disease Associated with Central Obesity Journal of Personalized Medicine peptic ulcer disease metabolic syndrome central obesity health examination |
| title | Peptic Ulcer Disease Associated with Central Obesity |
| title_full | Peptic Ulcer Disease Associated with Central Obesity |
| title_fullStr | Peptic Ulcer Disease Associated with Central Obesity |
| title_full_unstemmed | Peptic Ulcer Disease Associated with Central Obesity |
| title_short | Peptic Ulcer Disease Associated with Central Obesity |
| title_sort | peptic ulcer disease associated with central obesity |
| topic | peptic ulcer disease metabolic syndrome central obesity health examination |
| url | https://www.mdpi.com/2075-4426/12/12/1968 |
| work_keys_str_mv | AT songsengloke pepticulcerdiseaseassociatedwithcentralobesity AT wenchengli pepticulcerdiseaseassociatedwithcentralobesity |