H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells

H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells

Summary: Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in histone 3 (H3.3 or H3.1) resulting in a lysine-to-methionine substitution (H3K27M). Patients with DIPG have...

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Bibliographic Details
Main Authors: Katarzyna B. Leszczynska, Amanda Freitas-Huhtamäki, Chinchu Jayaprakash, Monika Dzwigonska, Francisca N.L. Vitorino, Cynthia Horth, Kamil Wojnicki, Bartlomiej Gielniewski, Paulina Szadkowska, Beata Kaza, Javad Nazarian, Maciej K. Ciolkowski, Joanna Trubicka, Wieslawa Grajkowska, Benjamin A. Garcia, Jacek Majewski, Bozena Kaminska, Jakub Mieczkowski
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724000354

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