Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia
Background: Colorectal cancer is one of the most common malignancies in the Western world, and is responsible for about 10% of annual cancer-related deaths. Especially for UICC stage IV, the probability of survival is significantly reduced. Little is known about risk factors for specific metastatic...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/28/6/423 |
| _version_ | 1797505595982479360 |
|---|---|
| author | Markus S. Jördens Simon Labuhn Tom Luedde Laura Hoyer Karel Kostev Sven H. Loosen Christoph Roderburg |
| author_facet | Markus S. Jördens Simon Labuhn Tom Luedde Laura Hoyer Karel Kostev Sven H. Loosen Christoph Roderburg |
| author_sort | Markus S. Jördens |
| collection | DOAJ |
| description | Background: Colorectal cancer is one of the most common malignancies in the Western world, and is responsible for about 10% of annual cancer-related deaths. Especially for UICC stage IV, the probability of survival is significantly reduced. Little is known about risk factors for specific metastatic patterns of colorectal cancer that may also influence patients’ overall survival. Methods: We used data from the IQVIA oncology dynamics (OD) database to determine the prevalence of pulmonary metastases in 19,321 patients with UICC stage IV colorectal cancer in eight European and Asian countries. Results: In total, 6132 of 19,321 (31.7%) study patients had lung metastases, with a higher prevalence among patients with rectal (37.5%) than colon (30.1%) cancer. When compared to China as the country with the lowest lung metastases prevalence, the odds for lung metastases were highest in UK (OR: 2.02, 95%CI: 1.80–2.28), followed by Italy (OR: 1.86, 95%CI: 1.52–2.27), Spain (OR: 1.85, 95%CI: 1.64–2.09), and Germany (OR: 1.47, 95%CI: 1.26–1.71). Conclusion: The prevalence of pulmonary metastases in UICC stage IV colorectal cancer varies widely among the different analyzed countries. Although the present data are purely descriptive, a possible combination of ethnic, environmental, and health care system-associated differences could be discussed as the underlying cause. Further studies are needed to investigate the reasons for differences in the prevalence of lung metastases. |
| first_indexed | 2024-03-10T04:20:52Z |
| format | Article |
| id | doaj.art-5905c94314a340bfbc6c0ba579f7ca15 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T04:20:52Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-5905c94314a340bfbc6c0ba579f7ca152023-11-23T07:50:53ZengMDPI AGCurrent Oncology1198-00521718-77292021-11-012865035504010.3390/curroncol28060423Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and AsiaMarkus S. Jördens0Simon Labuhn1Tom Luedde2Laura Hoyer3Karel Kostev4Sven H. Loosen5Christoph Roderburg6Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyEpidemiology, IQVIA, 60549 Frankfurt, GermanyEpidemiology, IQVIA, 60549 Frankfurt, GermanyDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, Medical Faculty of Heinrich Heine University Düsseldorf, 40225 Düsseldorf, GermanyBackground: Colorectal cancer is one of the most common malignancies in the Western world, and is responsible for about 10% of annual cancer-related deaths. Especially for UICC stage IV, the probability of survival is significantly reduced. Little is known about risk factors for specific metastatic patterns of colorectal cancer that may also influence patients’ overall survival. Methods: We used data from the IQVIA oncology dynamics (OD) database to determine the prevalence of pulmonary metastases in 19,321 patients with UICC stage IV colorectal cancer in eight European and Asian countries. Results: In total, 6132 of 19,321 (31.7%) study patients had lung metastases, with a higher prevalence among patients with rectal (37.5%) than colon (30.1%) cancer. When compared to China as the country with the lowest lung metastases prevalence, the odds for lung metastases were highest in UK (OR: 2.02, 95%CI: 1.80–2.28), followed by Italy (OR: 1.86, 95%CI: 1.52–2.27), Spain (OR: 1.85, 95%CI: 1.64–2.09), and Germany (OR: 1.47, 95%CI: 1.26–1.71). Conclusion: The prevalence of pulmonary metastases in UICC stage IV colorectal cancer varies widely among the different analyzed countries. Although the present data are purely descriptive, a possible combination of ethnic, environmental, and health care system-associated differences could be discussed as the underlying cause. Further studies are needed to investigate the reasons for differences in the prevalence of lung metastases.https://www.mdpi.com/1718-7729/28/6/423CRCcolorectallung metastasesprevalence |
| spellingShingle | Markus S. Jördens Simon Labuhn Tom Luedde Laura Hoyer Karel Kostev Sven H. Loosen Christoph Roderburg Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia Current Oncology CRC colorectal lung metastases prevalence |
| title | Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia |
| title_full | Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia |
| title_fullStr | Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia |
| title_full_unstemmed | Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia |
| title_short | Prevalence of Lung Metastases among 19,321 Metastatic Colorectal Cancer Patients in Eight Countries of Europe and Asia |
| title_sort | prevalence of lung metastases among 19 321 metastatic colorectal cancer patients in eight countries of europe and asia |
| topic | CRC colorectal lung metastases prevalence |
| url | https://www.mdpi.com/1718-7729/28/6/423 |
| work_keys_str_mv | AT markussjordens prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia AT simonlabuhn prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia AT tomluedde prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia AT laurahoyer prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia AT karelkostev prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia AT svenhloosen prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia AT christophroderburg prevalenceoflungmetastasesamong19321metastaticcolorectalcancerpatientsineightcountriesofeuropeandasia |