Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease
Deep brain stimulation (DBS) has significant effects on motor symptoms in Parkinson's disease (PD), but existing studies on the effect of DBS on speech are rather inconclusive. It is assumed that deficits in auditory-motor integration strongly contribute to Parkinsonian speech pathology. The ai...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2020.00655/full |
| _version_ | 1818061357448167424 |
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| author | Bahne H. Bahners Esther Florin Julian Rohrhuber Holger Krause Jan Hirschmann Ruben van de Vijver Alfons Schnitzler Alfons Schnitzler Markus Butz |
| author_facet | Bahne H. Bahners Esther Florin Julian Rohrhuber Holger Krause Jan Hirschmann Ruben van de Vijver Alfons Schnitzler Alfons Schnitzler Markus Butz |
| author_sort | Bahne H. Bahners |
| collection | DOAJ |
| description | Deep brain stimulation (DBS) has significant effects on motor symptoms in Parkinson's disease (PD), but existing studies on the effect of DBS on speech are rather inconclusive. It is assumed that deficits in auditory-motor integration strongly contribute to Parkinsonian speech pathology. The aim of the present study was to assess whether subthalamic DBS can modulate these deficits. Twenty PD patients (15 male, 5 female; 62.4 ± 6.7 years) with subthalamic DBS were exposed to pitch-shifted acoustic feedback during vowel vocalization and subsequent listening. Voice and brain activity were measured ON and OFF stimulation using magnetoencephalography (MEG). Vocal responses and auditory evoked responses time locked to the onset of pitch-shifted feedback were examined. A positive correlation between vocal response magnitude and pitch variability was observed for both, stimulation ON and OFF (ON: r = 0.722, p < 0.001, OFF: r = 0.746, p < 0.001). However, no differences of vocal responses to pitch-shifted feedback between the stimulation conditions were found [t(19) = −0.245, p = 0.809, d = −0.055]. P200m amplitudes of event related fields (ERF) of left and right auditory cortex (AC) and superior temporal gyrus (STG) were significantly larger during listening [left AC P200m: F(1, 19) = 10.241, p = 0.005, f = 0.734; right STG P200m: F(1, 19) = 8.393, p = 0.009, f = 0.664]. Subthalamic DBS appears to have no substantial effect on vocal compensations, although it has been suggested that auditory-motor integration deficits contribute to higher vocal response magnitudes in pitch perturbation experiments with PD patients. Thus, DBS seems to be limited in modulating auditory-motor integration of speech in PD. |
| first_indexed | 2024-12-10T13:47:02Z |
| format | Article |
| id | doaj.art-59086f2433fa44c0a43ed66a9c2860a3 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T13:47:02Z |
| publishDate | 2020-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-59086f2433fa44c0a43ed66a9c2860a32022-12-22T01:46:21ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-07-011110.3389/fneur.2020.00655547739Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's DiseaseBahne H. Bahners0Esther Florin1Julian Rohrhuber2Holger Krause3Jan Hirschmann4Ruben van de Vijver5Alfons Schnitzler6Alfons Schnitzler7Markus Butz8Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyCenter for Movement Disorders and Neuromodulation, Department of Neurology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Linguistics and Information Science, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyDepartment of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty, University Hospital Düsseldorf, Düsseldorf, GermanyInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, GermanyDeep brain stimulation (DBS) has significant effects on motor symptoms in Parkinson's disease (PD), but existing studies on the effect of DBS on speech are rather inconclusive. It is assumed that deficits in auditory-motor integration strongly contribute to Parkinsonian speech pathology. The aim of the present study was to assess whether subthalamic DBS can modulate these deficits. Twenty PD patients (15 male, 5 female; 62.4 ± 6.7 years) with subthalamic DBS were exposed to pitch-shifted acoustic feedback during vowel vocalization and subsequent listening. Voice and brain activity were measured ON and OFF stimulation using magnetoencephalography (MEG). Vocal responses and auditory evoked responses time locked to the onset of pitch-shifted feedback were examined. A positive correlation between vocal response magnitude and pitch variability was observed for both, stimulation ON and OFF (ON: r = 0.722, p < 0.001, OFF: r = 0.746, p < 0.001). However, no differences of vocal responses to pitch-shifted feedback between the stimulation conditions were found [t(19) = −0.245, p = 0.809, d = −0.055]. P200m amplitudes of event related fields (ERF) of left and right auditory cortex (AC) and superior temporal gyrus (STG) were significantly larger during listening [left AC P200m: F(1, 19) = 10.241, p = 0.005, f = 0.734; right STG P200m: F(1, 19) = 8.393, p = 0.009, f = 0.664]. Subthalamic DBS appears to have no substantial effect on vocal compensations, although it has been suggested that auditory-motor integration deficits contribute to higher vocal response magnitudes in pitch perturbation experiments with PD patients. Thus, DBS seems to be limited in modulating auditory-motor integration of speech in PD.https://www.frontiersin.org/article/10.3389/fneur.2020.00655/fullauditory feedbacksubthalamic nucleusauditory cortexevent related fieldsmagnetoencephalography (MEG)artifacts |
| spellingShingle | Bahne H. Bahners Esther Florin Julian Rohrhuber Holger Krause Jan Hirschmann Ruben van de Vijver Alfons Schnitzler Alfons Schnitzler Markus Butz Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease Frontiers in Neurology auditory feedback subthalamic nucleus auditory cortex event related fields magnetoencephalography (MEG) artifacts |
| title | Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease |
| title_full | Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease |
| title_fullStr | Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease |
| title_full_unstemmed | Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease |
| title_short | Deep Brain Stimulation Does Not Modulate Auditory-Motor Integration of Speech in Parkinson's Disease |
| title_sort | deep brain stimulation does not modulate auditory motor integration of speech in parkinson s disease |
| topic | auditory feedback subthalamic nucleus auditory cortex event related fields magnetoencephalography (MEG) artifacts |
| url | https://www.frontiersin.org/article/10.3389/fneur.2020.00655/full |
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