Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD
Non-alcoholic fatty liver disease (NAFLD) is becoming the predominant liver disease worldwide, and vitamin E has been clinically shown to improve histological parameters in a subset of patients. In this narrative review, we investigate whether genetic factors may help to explain why some patients sh...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/7/1284 |
| _version_ | 1797407764850409472 |
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| author | Mehtap Civelek Maren C. Podszun |
| author_facet | Mehtap Civelek Maren C. Podszun |
| author_sort | Mehtap Civelek |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is becoming the predominant liver disease worldwide, and vitamin E has been clinically shown to improve histological parameters in a subset of patients. In this narrative review, we investigate whether genetic factors may help to explain why some patients show histological improvements upon high-dose alpha-tocopherol (αT) treatment while others do not. In summary, we identified two factors that are associated with treatment response, including genetic variations in haptoglobin as well as fatty acid desaturase 1/2 (FADS1/FADS2). Other genetic variants such as in alpha-tocopherol transfer protein (αTTP), tocopherol associated protein (TAP), transmembrane 6 superfamily 2 (TM6SF2), cluster of differentiation 36 (CD36), and proteins involved in lipoprotein metabolism may also play a role, but have not yet been investigated in a clinical context. We propose to further validate these associations in larger populations, to then use them as a clinical tool to identify the subset of patients that will benefit the most from vitamin E supplementation. |
| first_indexed | 2024-03-09T03:46:22Z |
| format | Article |
| id | doaj.art-590918a7103541188dfb6e76514073d7 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:46:22Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-590918a7103541188dfb6e76514073d72023-12-03T14:33:47ZengMDPI AGAntioxidants2076-39212022-06-01117128410.3390/antiox11071284Genetic Factors Associated with Response to Vitamin E Treatment in NAFLDMehtap Civelek0Maren C. Podszun1Department of Nutrition and Dietetics, Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, GermanyDepartment of Nutrition and Dietetics, Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, GermanyNon-alcoholic fatty liver disease (NAFLD) is becoming the predominant liver disease worldwide, and vitamin E has been clinically shown to improve histological parameters in a subset of patients. In this narrative review, we investigate whether genetic factors may help to explain why some patients show histological improvements upon high-dose alpha-tocopherol (αT) treatment while others do not. In summary, we identified two factors that are associated with treatment response, including genetic variations in haptoglobin as well as fatty acid desaturase 1/2 (FADS1/FADS2). Other genetic variants such as in alpha-tocopherol transfer protein (αTTP), tocopherol associated protein (TAP), transmembrane 6 superfamily 2 (TM6SF2), cluster of differentiation 36 (CD36), and proteins involved in lipoprotein metabolism may also play a role, but have not yet been investigated in a clinical context. We propose to further validate these associations in larger populations, to then use them as a clinical tool to identify the subset of patients that will benefit the most from vitamin E supplementation.https://www.mdpi.com/2076-3921/11/7/1284vitamin ENAFLDresponse to treatmentgenetic factors |
| spellingShingle | Mehtap Civelek Maren C. Podszun Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD Antioxidants vitamin E NAFLD response to treatment genetic factors |
| title | Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD |
| title_full | Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD |
| title_fullStr | Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD |
| title_full_unstemmed | Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD |
| title_short | Genetic Factors Associated with Response to Vitamin E Treatment in NAFLD |
| title_sort | genetic factors associated with response to vitamin e treatment in nafld |
| topic | vitamin E NAFLD response to treatment genetic factors |
| url | https://www.mdpi.com/2076-3921/11/7/1284 |
| work_keys_str_mv | AT mehtapcivelek geneticfactorsassociatedwithresponsetovitaminetreatmentinnafld AT marencpodszun geneticfactorsassociatedwithresponsetovitaminetreatmentinnafld |