Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms

Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms

The central mechanism by which neurotensin (Nts) potentiates weight loss has remained elusive. We leveraged chemogenetics to reveal that Nts-expressing neurons of the lateral hypothalamic area (LHA) promote weight loss in mice by increasing volitional activity and restraining food intake. Intriguing...

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Bibliographic Details
Main Authors: Hillary L. Woodworth, Bethany G. Beekly, Hannah M. Batchelor, Raluca Bugescu, Patricia Perez-Bonilla, Laura E. Schroeder, Gina M. Leinninger
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Subjects:
neurotensin
neurotensin receptor
lateral hypothalamic area
feeding
locomotor activity
drinking
obesity
energy balance
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717317205

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