Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma
Abstract Zinc finger proteins are transcription factors with the finger domain, which plays a significant role in gene regulation. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | Biomarker Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40364-021-00345-1 |
| _version_ | 1818752823134781440 |
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| author | Xinxin Li Mengzhen Han Hongwei Zhang Furong Liu Yonglong Pan Jinghan Zhu Zhibin Liao Xiaoping Chen Bixiang Zhang |
| author_facet | Xinxin Li Mengzhen Han Hongwei Zhang Furong Liu Yonglong Pan Jinghan Zhu Zhibin Liao Xiaoping Chen Bixiang Zhang |
| author_sort | Xinxin Li |
| collection | DOAJ |
| description | Abstract Zinc finger proteins are transcription factors with the finger domain, which plays a significant role in gene regulation. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. Different kinds of zinc finger motifs exhibit a wide variety of biological functions. Zinc finger proteins have been reported in various diseases, especially in several cancers. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide, especially in China. Most of HCC patients have suffered from hepatitis B virus (HBV) and hepatitis C virus (HCV) injection for a long time. Although the surgical operation of HCC has been extremely developed, the prognosis of HCC is still very poor, and the underlying mechanisms in HCC tumorigenesis are still not completely understood. Here, we summarize multiple functions and recent research of zinc finger proteins in HCC tumorigenesis and progression. We also discuss the significance of zinc finger proteins in HCC diagnosis and prognostic evaluation. |
| first_indexed | 2024-12-18T04:57:35Z |
| format | Article |
| id | doaj.art-591196526f0549c1863deaf3e5dc9ffb |
| institution | Directory Open Access Journal |
| issn | 2050-7771 |
| language | English |
| last_indexed | 2024-12-18T04:57:35Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Biomarker Research |
| spelling | doaj.art-591196526f0549c1863deaf3e5dc9ffb2022-12-21T21:20:14ZengBMCBiomarker Research2050-77712022-01-0110111310.1186/s40364-021-00345-1Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinomaXinxin Li0Mengzhen Han1Hongwei Zhang2Furong Liu3Yonglong Pan4Jinghan Zhu5Zhibin Liao6Xiaoping Chen7Bixiang Zhang8Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyHepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Zinc finger proteins are transcription factors with the finger domain, which plays a significant role in gene regulation. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. Different kinds of zinc finger motifs exhibit a wide variety of biological functions. Zinc finger proteins have been reported in various diseases, especially in several cancers. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death worldwide, especially in China. Most of HCC patients have suffered from hepatitis B virus (HBV) and hepatitis C virus (HCV) injection for a long time. Although the surgical operation of HCC has been extremely developed, the prognosis of HCC is still very poor, and the underlying mechanisms in HCC tumorigenesis are still not completely understood. Here, we summarize multiple functions and recent research of zinc finger proteins in HCC tumorigenesis and progression. We also discuss the significance of zinc finger proteins in HCC diagnosis and prognostic evaluation.https://doi.org/10.1186/s40364-021-00345-1Zinc finger proteinTranscription factorHepatocellular carcinomaTranscription regulationBiological function |
| spellingShingle | Xinxin Li Mengzhen Han Hongwei Zhang Furong Liu Yonglong Pan Jinghan Zhu Zhibin Liao Xiaoping Chen Bixiang Zhang Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma Biomarker Research Zinc finger protein Transcription factor Hepatocellular carcinoma Transcription regulation Biological function |
| title | Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma |
| title_full | Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma |
| title_fullStr | Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma |
| title_full_unstemmed | Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma |
| title_short | Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma |
| title_sort | structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma |
| topic | Zinc finger protein Transcription factor Hepatocellular carcinoma Transcription regulation Biological function |
| url | https://doi.org/10.1186/s40364-021-00345-1 |
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