The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene

The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene

Human papillomaviruses (HPV) replicate their DNA in the suprabasal layer of the infected mucosa or skin. In order to create a suitable environment for vegetative viral DNA replication HPV delay differentiation and sustain keratinocyte proliferation that can lead to hyperplasia. The mechanism underly...

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Bibliographic Details
Main Authors: Stefanie Taute, Philipp Böhnke, Jasmin Sprissler, Stephanie Buchholz, Martin Hufbauer, Baki Akgül, Gertrud Steger
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cells
Subjects:
Human papillomaviruses (HPV)
HPV8
E6 oncoprotein
protein tyrosine phosphatase H1 (PTPH1)
EGFR
active Ras
keratinocyte proliferation
Online Access:http://www.mdpi.com/2073-4409/8/3/244

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