Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis.
The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.Eligible publications were retrieved acc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4334541?pdf=render |
| _version_ | 1817989364817330176 |
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| author | Qiang Cai Jian Wu Qu Cai Er-Zhen Chen Zhao-Yan Jiang |
| author_facet | Qiang Cai Jian Wu Qu Cai Er-Zhen Chen Zhao-Yan Jiang |
| author_sort | Qiang Cai |
| collection | DOAJ |
| description | The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I2 = 93%).Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population. |
| first_indexed | 2024-04-14T00:46:04Z |
| format | Article |
| id | doaj.art-5915bb8c90324beb8833457fee8e0b54 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T00:46:04Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-5915bb8c90324beb8833457fee8e0b542022-12-22T02:22:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01102e011717310.1371/journal.pone.0117173Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis.Qiang CaiJian WuQu CaiEr-Zhen ChenZhao-Yan JiangThe association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I2 = 93%).Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.http://europepmc.org/articles/PMC4334541?pdf=render |
| spellingShingle | Qiang Cai Jian Wu Qu Cai Er-Zhen Chen Zhao-Yan Jiang Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. PLoS ONE |
| title | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. |
| title_full | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. |
| title_fullStr | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. |
| title_full_unstemmed | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. |
| title_short | Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. |
| title_sort | association between glu504lys polymorphism of aldh2 gene and cancer risk a meta analysis |
| url | http://europepmc.org/articles/PMC4334541?pdf=render |
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