Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma
Introduction: Mantle cell lymphoma (MCL), a rare non-Hodgkin’s lymphoma, exhibits a genetic translocation causing CCND1 gene overexpression, affecting 5% of NHL cases, predominantly in males aged 60–70. Typically diagnosed with advanced symptoms, MCL involves widespread disease and organ spread, bei...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2024-06-01
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| Series: | Case Reports in Gastroenterology |
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| Online Access: | https://beta.karger.com/Article/FullText/539288 |
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| author | Rahil Desai Katherine Khazey Hasnoor Sandhu Peter Makar Navkiran Randhawa Ahamed Khalyfa Mahnoor Khan Alex Yarbrough Tilemahos Spyratos |
| author_facet | Rahil Desai Katherine Khazey Hasnoor Sandhu Peter Makar Navkiran Randhawa Ahamed Khalyfa Mahnoor Khan Alex Yarbrough Tilemahos Spyratos |
| author_sort | Rahil Desai |
| collection | DOAJ |
| description | Introduction: Mantle cell lymphoma (MCL), a rare non-Hodgkin’s lymphoma, exhibits a genetic translocation causing CCND1 gene overexpression, affecting 5% of NHL cases, predominantly in males aged 60–70. Typically diagnosed with advanced symptoms, MCL involves widespread disease and organ spread, being aggressive and incurable with a 1.8–9.4-year average survival. Optimal treatment depends on disease aggressiveness and age. Multiple lymphomatous polyposis (MLP), a rare MCL subtype in the GI tract, is usually present with GI symptoms. Case Presentation: A 71-year-old woman was diagnosed with asymptomatic MLP during MCL staging who underwent thoracentesis due to large right pleural effusion and significant axillary lymphadenopathy and was treated with a chemotherapy regimen of rituximab/cytarabine and later transitioned to bendamustine/rituximab. This patient eventually underwent a bone marrow biopsy and later a bone marrow transplant. Conclusion: We present a unique case of asymptomatic MLP, emphasizing the importance of early detection for the poor prognosis of MLP with a mean survival of less than 3 years. |
| first_indexed | 2025-03-21T08:43:29Z |
| format | Article |
| id | doaj.art-5916641b6cc64cc9a901b8256983e01c |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2025-03-21T08:43:29Z |
| publishDate | 2024-06-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-5916641b6cc64cc9a901b8256983e01c2024-07-11T13:39:36ZengKarger PublishersCase Reports in Gastroenterology1662-06312024-06-0118131331710.1159/000539288539288Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell LymphomaRahil Desai0Katherine Khazey1Hasnoor Sandhu2Peter Makar3Navkiran Randhawa4Ahamed Khalyfa5Mahnoor Khan6Alex Yarbrough7Tilemahos Spyratos8Franciscan Health Olympia Fields Hospital, Olympia Fields, IL, USAFranciscan Health Olympia Fields Hospital, Olympia Fields, IL, USAFranciscan Health Olympia Fields Hospital, Olympia Fields, IL, USAFranciscan Health Olympia Fields Hospital, Olympia Fields, IL, USADepartment of Gastroenterology, Medical College of Georgia, Augusta University, Augusta, GA, USADepartment of Gastroenterology, University of Iowa, Iowa City, IA, USADepartment of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USAFranciscan Health Olympia Fields Hospital, Olympia Fields, IL, USAFranciscan Health Olympia Fields Hospital, Olympia Fields, IL, USAIntroduction: Mantle cell lymphoma (MCL), a rare non-Hodgkin’s lymphoma, exhibits a genetic translocation causing CCND1 gene overexpression, affecting 5% of NHL cases, predominantly in males aged 60–70. Typically diagnosed with advanced symptoms, MCL involves widespread disease and organ spread, being aggressive and incurable with a 1.8–9.4-year average survival. Optimal treatment depends on disease aggressiveness and age. Multiple lymphomatous polyposis (MLP), a rare MCL subtype in the GI tract, is usually present with GI symptoms. Case Presentation: A 71-year-old woman was diagnosed with asymptomatic MLP during MCL staging who underwent thoracentesis due to large right pleural effusion and significant axillary lymphadenopathy and was treated with a chemotherapy regimen of rituximab/cytarabine and later transitioned to bendamustine/rituximab. This patient eventually underwent a bone marrow biopsy and later a bone marrow transplant. Conclusion: We present a unique case of asymptomatic MLP, emphasizing the importance of early detection for the poor prognosis of MLP with a mean survival of less than 3 years.https://beta.karger.com/Article/FullText/539288amlpathologymultiple lymphomatous polyposislymphomacase report |
| spellingShingle | Rahil Desai Katherine Khazey Hasnoor Sandhu Peter Makar Navkiran Randhawa Ahamed Khalyfa Mahnoor Khan Alex Yarbrough Tilemahos Spyratos Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma Case Reports in Gastroenterology aml pathology multiple lymphomatous polyposis lymphoma case report |
| title | Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma |
| title_full | Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma |
| title_fullStr | Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma |
| title_full_unstemmed | Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma |
| title_short | Gastrointestinal Symptom-Free Multiple Lymphomatous Polyposis: An Atypical Case Presentation of Mantle Cell Lymphoma |
| title_sort | gastrointestinal symptom free multiple lymphomatous polyposis an atypical case presentation of mantle cell lymphoma |
| topic | aml pathology multiple lymphomatous polyposis lymphoma case report |
| url | https://beta.karger.com/Article/FullText/539288 |
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