Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes.

We quantified CD8 T cells needed to cause type 1 diabetes and studied the anatomy of the CD8 T cell/beta (β) cell interaction at the immunologic synapse. We used a transgenic model, in situ tetramer staining to distinguish antigen specific CD8 T cells from total T cells infiltrating islets and a var...

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Bibliographic Details
Main Authors: Michael B A Oldstone, Kurt H Edelmann, Dorian B McGavern, Justin T Cruite, Megan J Welch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3510245?pdf=render

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