Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway.

Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway.

Fat infiltration within marrow cavity is one of multitudinous features of estrogen deficiency, which leads to a decline in bone formation functionality. The origin of this fat is unclear, but one possibility is that it is derived from osteoblasts, which transdifferentiate into adipocytes that produc...

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Bibliographic Details
Main Authors: Bo Gao, Qiang Huang, Yan-Shui Lin, Bo-Yuan Wei, Yun-Shan Guo, Zhen Sun, Long Wang, Jing Fan, Hong-Yang Zhang, Yue-Hu Han, Xiao-Jie Li, Jun Shi, Jian Liu, Liu Yang, Zhuo-Jing Luo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4053448?pdf=render

Internet

http://europepmc.org/articles/PMC4053448?pdf=render

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