Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity

Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity

Abstract Drug resistance is a fundamental clinical concern in pediatric acute lymphoblastic leukemia (pALL), and methotrexate (MTX) is an essential chemotherapy drug administered for the treatment. In the current study, the effect of iron in response to methotrexate and its underlying mechanisms wer...

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Bibliographic Details
Main Authors: Marjan Abedi, Soheila Rahgozar, Abolghasem Esmaeili
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Cancer Medicine
Subjects:
acute lymphoblastic leukemia
drug resistance
iron
methotrexate
Online Access:https://doi.org/10.1002/cam4.2982

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