Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells
Cryopreservation is standard protocol prior to using NK cells in immunotherapy. Here the authors show that cryopreservation substantially reduces the clinical utility of these cells owing to a defect in their motility, an effect that might account for failure to treat some cancers with NK cell immun...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-19094-0 |
| _version_ | 1818355736334303232 |
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| author | Christoph Mark Tina Czerwinski Susanne Roessner Astrid Mainka Franziska Hörsch Lucas Heublein Alexander Winterl Sebastian Sanokowski Sebastian Richter Nina Bauer Thomas E. Angelini Gerold Schuler Ben Fabry Caroline J. Voskens |
| author_facet | Christoph Mark Tina Czerwinski Susanne Roessner Astrid Mainka Franziska Hörsch Lucas Heublein Alexander Winterl Sebastian Sanokowski Sebastian Richter Nina Bauer Thomas E. Angelini Gerold Schuler Ben Fabry Caroline J. Voskens |
| author_sort | Christoph Mark |
| collection | DOAJ |
| description | Cryopreservation is standard protocol prior to using NK cells in immunotherapy. Here the authors show that cryopreservation substantially reduces the clinical utility of these cells owing to a defect in their motility, an effect that might account for failure to treat some cancers with NK cell immunotherapy. |
| first_indexed | 2024-12-13T19:46:03Z |
| format | Article |
| id | doaj.art-592277d811384c5e9cee33092259a432 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T19:46:03Z |
| publishDate | 2020-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-592277d811384c5e9cee33092259a4322022-12-21T23:33:33ZengNature PortfolioNature Communications2041-17232020-10-011111810.1038/s41467-020-19094-0Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cellsChristoph Mark0Tina Czerwinski1Susanne Roessner2Astrid Mainka3Franziska Hörsch4Lucas Heublein5Alexander Winterl6Sebastian Sanokowski7Sebastian Richter8Nina Bauer9Thomas E. Angelini10Gerold Schuler11Ben Fabry12Caroline J. Voskens13Friedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg and University Hospital Erlangen, Department of DermatologyFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsUniversity of Florida, Department of Mechanical and Aerospace EngineeringFriedrich-Alexander University Erlangen-Nürnberg and University Hospital Erlangen, Department of DermatologyFriedrich-Alexander University Erlangen-Nürnberg, Department of PhysicsFriedrich-Alexander University Erlangen-Nürnberg and University Hospital Erlangen, Department of DermatologyCryopreservation is standard protocol prior to using NK cells in immunotherapy. Here the authors show that cryopreservation substantially reduces the clinical utility of these cells owing to a defect in their motility, an effect that might account for failure to treat some cancers with NK cell immunotherapy.https://doi.org/10.1038/s41467-020-19094-0 |
| spellingShingle | Christoph Mark Tina Czerwinski Susanne Roessner Astrid Mainka Franziska Hörsch Lucas Heublein Alexander Winterl Sebastian Sanokowski Sebastian Richter Nina Bauer Thomas E. Angelini Gerold Schuler Ben Fabry Caroline J. Voskens Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells Nature Communications |
| title | Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells |
| title_full | Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells |
| title_fullStr | Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells |
| title_full_unstemmed | Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells |
| title_short | Cryopreservation impairs 3-D migration and cytotoxicity of natural killer cells |
| title_sort | cryopreservation impairs 3 d migration and cytotoxicity of natural killer cells |
| url | https://doi.org/10.1038/s41467-020-19094-0 |
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