METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development

METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development

Abstract Background 7-Methylguanosine (m7G) is one of the most conserved modifications in nucleosides within tRNAs and rRNAs. It plays essential roles in the regulation of mRNA export, splicing, and translation. Recent studies highlighted the importance of METTL1-mediated m7G tRNA methylome in the s...

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Bibliographic Details
Main Authors: Yujie Deng, Zhongyang Zhou, Weidong Ji, Shuibin Lin, Min Wang
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Stem Cell Research & Therapy
Subjects:
N7-methylguanosine (m7G)
Human induced pluripotent stem cells (hiPSCs)
Pluripotency
Differentiation
Mesoderm
Vasculogenesis
Online Access:http://link.springer.com/article/10.1186/s13287-020-01814-4

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