| Summary: | Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, <i>Perenniporia centrali-africana</i> (originating from Kenya) and <i>Cerrena</i> sp. nov. (originating from Thailand). A new pereniporin A derivative (<b>1</b>), a new drimane-type sesquiterpene lactam (<b>2</b>), and the new 6,7-Dehydro-isodrimenediol (<b>3</b>) were isolated from <i>P. centrali-africana.</i> In parallel, the two new drimane-type sesquiterpene lactams <b>5</b> and <b>6</b> were isolated together with known isodrimenediol (<b>4</b>) from <i>Cerrena</i> sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities.
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