Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic
Watip Tangjittipokin,1,2 Lanraphat Srisawat,1– 3 Nipaporn Teerawattanapong,1– 3 Tassanee Narkdontri,1– 3 Mayuree Homsanit,4 Nattachet Plengvidhya2,5 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence for Diab...
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| Format: | Article |
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Dove Medical Press
2022-07-01
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| Series: | Journal of Multidisciplinary Healthcare |
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| Online Access: | https://www.dovepress.com/prevalence-and-characteristics-of-prediabetes-and-metabolic-syndrome-i-peer-reviewed-fulltext-article-JMDH |
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| author | Tangjittipokin W Srisawat L Teerawattanapong N Narkdontri T Homsanit M Plengvidhya N |
| author_facet | Tangjittipokin W Srisawat L Teerawattanapong N Narkdontri T Homsanit M Plengvidhya N |
| author_sort | Tangjittipokin W |
| collection | DOAJ |
| description | Watip Tangjittipokin,1,2 Lanraphat Srisawat,1– 3 Nipaporn Teerawattanapong,1– 3 Tassanee Narkdontri,1– 3 Mayuree Homsanit,4 Nattachet Plengvidhya2,5 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), Faculty of Medicine Siriraj, Mahidol University, Bangkok, Thailand; 3Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 5Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Nattachet Plengvidhya, Division of Endocrinology and Metabolism, Department of Medicine Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand, Tel +66 2-416-7797, Fax +66 2-419-7792, Email sinpv.natpl@gmail.comPurpose: This study investigated the prevalence and characteristics of prediabetes (PreDM) and metabolic syndrome (MetS) in seemingly healthy persons attending a health check-up clinic at a tertiary care hospital.Patients and Methods: This was a cross-sectional study that enrolled 1213 subjects (339 male, 874 female) who underwent an annual health check-up at Siriraj Hospital, Bangkok, Thailand from 2009 to 2019. Factors that independently related to PreDM were analyzed using unconditional logistic regression analysis with adjustments for age, BMI, and gender.Results: The prevalence of PreDM and MetS was 54.3% and 19.7% respectively. Participants with impaired fasting glucose (IFG) and glycated hemoglobin (HbA1c) 38.8– 46.4 mmol/mol had significantly higher waist circumference (WC) and blood pressure (BP) compared to those with IFG or HbA1c 38.8– 46.4 mmol/mol alone (P < 0.05). Among three PreDM subgroups, the average age was lowest in the HbA1c 38.8– 46.4 mmol/mol subgroup (P < 0.001). PreDM participants with MetS were older (p = 0.03), had higher WC, BP, fasting plasma glucose and serum triglyceride level (all P < 0.001) but had lower serum high-density lipoprotein (HDL) cholesterol level (P < 0.001). Multivariate analysis revealed high MetS score, obesity, and low serum HDL cholesterol level to be independently associated with PreDM with odds ratios of 9.02 (95% confidence interval [CI]: 4.03– 20.18), 1.8 (95% CI: 1.07– 3.04), and 1.42 (95% CI: 1.02– 1.96), respectively.Conclusion: The prevalence of PreDM and MetS was relatively high in seemingly healthy persons. Distinct PreDM subgroups with or without MetS exhibited diverse clinical and biochemical features suggesting dissimilar pathogenesis.Keywords: seemingly healthy persons, health check-up clinic, prediabetes, metabolic syndrome |
| first_indexed | 2024-04-13T20:12:46Z |
| format | Article |
| id | doaj.art-59250086f0c14200977c724e932b2582 |
| institution | Directory Open Access Journal |
| issn | 1178-2390 |
| language | English |
| last_indexed | 2024-04-13T20:12:46Z |
| publishDate | 2022-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Multidisciplinary Healthcare |
| spelling | doaj.art-59250086f0c14200977c724e932b25822022-12-22T02:31:48ZengDove Medical PressJournal of Multidisciplinary Healthcare1178-23902022-07-01Volume 151585159476755Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up ClinicTangjittipokin WSrisawat LTeerawattanapong NNarkdontri THomsanit MPlengvidhya NWatip Tangjittipokin,1,2 Lanraphat Srisawat,1– 3 Nipaporn Teerawattanapong,1– 3 Tassanee Narkdontri,1– 3 Mayuree Homsanit,4 Nattachet Plengvidhya2,5 1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 2Siriraj Center of Research Excellence for Diabetes and Obesity (SiCORE-DO), Faculty of Medicine Siriraj, Mahidol University, Bangkok, Thailand; 3Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 4Department of Preventive and Social Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; 5Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Nattachet Plengvidhya, Division of Endocrinology and Metabolism, Department of Medicine Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand, Tel +66 2-416-7797, Fax +66 2-419-7792, Email sinpv.natpl@gmail.comPurpose: This study investigated the prevalence and characteristics of prediabetes (PreDM) and metabolic syndrome (MetS) in seemingly healthy persons attending a health check-up clinic at a tertiary care hospital.Patients and Methods: This was a cross-sectional study that enrolled 1213 subjects (339 male, 874 female) who underwent an annual health check-up at Siriraj Hospital, Bangkok, Thailand from 2009 to 2019. Factors that independently related to PreDM were analyzed using unconditional logistic regression analysis with adjustments for age, BMI, and gender.Results: The prevalence of PreDM and MetS was 54.3% and 19.7% respectively. Participants with impaired fasting glucose (IFG) and glycated hemoglobin (HbA1c) 38.8– 46.4 mmol/mol had significantly higher waist circumference (WC) and blood pressure (BP) compared to those with IFG or HbA1c 38.8– 46.4 mmol/mol alone (P < 0.05). Among three PreDM subgroups, the average age was lowest in the HbA1c 38.8– 46.4 mmol/mol subgroup (P < 0.001). PreDM participants with MetS were older (p = 0.03), had higher WC, BP, fasting plasma glucose and serum triglyceride level (all P < 0.001) but had lower serum high-density lipoprotein (HDL) cholesterol level (P < 0.001). Multivariate analysis revealed high MetS score, obesity, and low serum HDL cholesterol level to be independently associated with PreDM with odds ratios of 9.02 (95% confidence interval [CI]: 4.03– 20.18), 1.8 (95% CI: 1.07– 3.04), and 1.42 (95% CI: 1.02– 1.96), respectively.Conclusion: The prevalence of PreDM and MetS was relatively high in seemingly healthy persons. Distinct PreDM subgroups with or without MetS exhibited diverse clinical and biochemical features suggesting dissimilar pathogenesis.Keywords: seemingly healthy persons, health check-up clinic, prediabetes, metabolic syndromehttps://www.dovepress.com/prevalence-and-characteristics-of-prediabetes-and-metabolic-syndrome-i-peer-reviewed-fulltext-article-JMDHseemingly healthy personshealth check-up clinicprediabetesmetabolic syndrome |
| spellingShingle | Tangjittipokin W Srisawat L Teerawattanapong N Narkdontri T Homsanit M Plengvidhya N Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic Journal of Multidisciplinary Healthcare seemingly healthy persons health check-up clinic prediabetes metabolic syndrome |
| title | Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic |
| title_full | Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic |
| title_fullStr | Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic |
| title_full_unstemmed | Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic |
| title_short | Prevalence and Characteristics of Prediabetes and Metabolic Syndrome in Seemingly Healthy Persons at a Health Check-Up Clinic |
| title_sort | prevalence and characteristics of prediabetes and metabolic syndrome in seemingly healthy persons at a health check up clinic |
| topic | seemingly healthy persons health check-up clinic prediabetes metabolic syndrome |
| url | https://www.dovepress.com/prevalence-and-characteristics-of-prediabetes-and-metabolic-syndrome-i-peer-reviewed-fulltext-article-JMDH |
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