Modeling Group B <italic toggle="yes">Streptococcus</italic> and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

Modeling Group B <italic toggle="yes">Streptococcus</italic> and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells

ABSTRACT Bacterial meningitis is a serious infection of the central nervous system (CNS) that occurs after bacteria interact with and penetrate the blood-brain barrier (BBB). The BBB is comprised of highly specialized brain microvascular endothelial cells (BMECs) that function to separate the circul...

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Bibliographic Details
Main Authors: Brandon J. Kim, Olivia B. Bee, Maura A. McDonagh, Matthew J. Stebbins, Sean P. Palecek, Kelly S. Doran, Eric V. Shusta
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mSphere
Subjects:
blood-brain barrier
group B Streptococcus
stem cells
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00398-17

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